Effect of DNA Supercoiling on Agarose Electrophoresis

The video tutorial by Kevin Tokoph at Catalyst University explains DNA electrophoresis in agarose gel, focusing on how DNA size and supercoiling affect migration. Using an analogy of crumpled paper, it illustrates how supercoiled DNA migrates faster due to reduced drag. The tutorial also introduces topological isomers and the role of topoisomerases in altering DNA supercoiling.

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