Understanding Primary Myelofibrosis

What is the primary issue in Primary Myelofibrosis?

• Increased platelet count

• Overproduction of red blood cells

• Replacement of bone marrow with connective tissue

• Excessive production of white blood cells

What does 'myeloid metaplasia' refer to in the context of Primary Myelofibrosis?

• Bone marrow producing excess cells

• Increased bone density

• Blood cell production occurring in the liver and spleen

• Bone marrow being replaced by fat

Which mutation is associated with Primary Myelofibrosis?

• EGFR mutation

• TP53 mutation

• JAK2 kinase mutation

• BRCA1 mutation

What symptom is caused by the enlargement of the spleen in Primary Myelofibrosis?

• Headache

• Skin rash

• Abdominal fullness

• Joint pain

What is a common sign of platelet deficiency in Primary Myelofibrosis?

• Frequent infections

• Weight gain

• Excessive bruising

• High blood pressure

How is a diagnosis of Primary Myelofibrosis confirmed?

• CT scan of the abdomen

• Peripheral blood smear showing teardrop-shaped red blood cells

• Ultrasound of the liver

• MRI scan

What does a 'dry tap' indicate during a bone marrow aspirate?

• Infection in the bone

• Presence of a tumor

• Excessive blood cell production

• Lack of bone marrow production

What is the only curative treatment for Primary Myelofibrosis?

• Radiation therapy

• Antibiotic therapy

• Stem cell transplantation

• Chemotherapy

Why might a splenectomy be performed in a patient with Primary Myelofibrosis?

• To increase red blood cell production

• To treat liver enlargement

• To alleviate severe abdominal fullness and discomfort

• To reduce high blood pressure

What temporary measure might be taken while waiting for a stem cell transplant in Primary Myelofibrosis?

• Dietary supplements

• Antiviral medication

• Blood transfusion

• Physical therapy