Chronic Myelogenous Leukemia (CML) Quiz

What is the primary genetic mutation involved in Chronic Myelogenous Leukemia?

• A duplication of chromosome 18

• A mutation in chromosome 21

• A translocation between chromosomes 9 and 22

• A deletion in chromosome 15

What is the Philadelphia chromosome?

• A chromosome that is unrelated to leukemia

• A chromosome that causes red blood cell overproduction

• A chromosome found only in acute leukemia

• A chromosome resulting from a translocation between chromosomes 9 and 22

Which type of stem cell is primarily involved in the excessive production of white blood cells in CML?

• Myeloid stem cell

• Lymphoid stem cell

• Megakaryocyte stem cell

• Erythroid stem cell

What is a common symptom during the chronic phase of CML?

• Severe headaches

• Frequent nosebleeds

• Abdominal fullness

• Severe bone pain

What characterizes the accelerated phase of CML?

• Rapid production of defective cells

• Stable cell production

• Rapid production of mature cells

• Decreased cell production

What is a potential side effect of the accelerated phase of CML?

• Reduced white blood cell count

• Increased risk of infections

• Improved platelet function

• Decreased metabolism

Which diagnostic test is considered a 'slam dunk' for identifying CML?

• Bone marrow aspiration

• Complete blood count

• Peripheral blood smear

• FISH test for Philadelphia chromosome

What is the role of Imatinib in the treatment of CML?

• It increases white blood cell production

• It stimulates red blood cell production

• It blocks the BCR-ABL protein

• It enhances platelet function

What is the significance of the BCR-ABL protein in CML?

• It prevents cell division

• It signals cells to divide continuously

• It repairs DNA mutations

• It reduces white blood cell production

What additional treatment might be necessary alongside Imatinib for CML patients?

• Chemotherapy

• Radiation therapy

• Allogeneic stem cell transplantation

• Surgical removal of the spleen