Understanding Monoclonal Gammopathy of Undetermined Significance (MGUS)

What is the primary function of plasma cells in the bone marrow?

• To produce red blood cells

• To produce antibodies

• To produce platelets

• To produce white blood cells

Which cell type is primarily involved in the dysfunction seen in MGUS?

• Plasma cell precursors

• Leukocyte precursors

• Thrombocyte precursors

• Erythrocyte precursors

What does the 'M' in M spike stand for in the context of MGUS?

• Mature

• Multiple

• Monoclonal

• Myeloma

What does the 'G' in MGUS stand for?

• Glandular

• Growth

• Genetic

• Gammopathy

Which of the following is a common test used to detect the M spike in MGUS?

• Protein electrophoresis

• Liver function test

• Complete blood count

• Blood glucose test

How does MGUS differ from multiple myeloma in terms of symptoms?

• MGUS is symptomatic, while multiple myeloma is not.

• MGUS is asymptomatic, while multiple myeloma presents symptoms.

• Both MGUS and multiple myeloma are asymptomatic.

• Both MGUS and multiple myeloma present symptoms.

Which of the following is NOT a symptom associated with the CRAB acronym for multiple myeloma?

• Hypercalcemia

• Renal failure

• Hypertension

• Anemia

What is the approximate annual risk of MGUS progressing to multiple myeloma?

• 0.1%

• 1%

• 5%

• 10%

What is the significance of the term 'undetermined' in MGUS?

• It suggests MGUS is not related to plasma cells.

• It means MGUS is a type of cancer.

• It reflects the uncertainty in predicting progression to multiple myeloma.

• It indicates that MGUS is always symptomatic.

What is the primary reason MGUS is considered of undetermined significance?

• It is difficult to predict who will develop multiple myeloma.

• It is a rare condition.

• It always leads to cancer.

• It has no known symptoms.