What is the primary focus of the video regarding lithocholic acid (LCA)?

• Its role in weight loss

• Its effects on mental health

• Its potential to mimic caloric restriction benefits

• Its use in treating diabetes

What is a significant downside of caloric restriction in humans?

• Increased appetite

• Muscle loss and frailty

• Higher risk of infections

• Decreased mental acuity

How many metabolites were identified as significantly altered by caloric restriction in the study?

• 695

• 100

• 1200

• 500

What effect did LCA have on muscle performance in mice?

• Lowered muscle regeneration

• Reduced mitochondrial content

• Increased oxidative fibers and grip strength

• Decreased running distance

What was the increase in median lifespan observed in flies when LCA was administered?

• 5%

• 11%

• 20%

• 15%

What is a common feature of anti-aging compounds when transitioning from mice to humans?

• Increased lifespan effects

• Minimal effects on lifespan but significant health span benefits

• No effects on health span

• Decreased lifespan effects

What dietary strategy is mentioned as potentially increasing LCA levels in humans?

• High-protein diet

• Fasting or ketogenic diet

• Low-fat diet

• Mediterranean diet

What enzyme does LCA activate that is also activated by fasting?

• AMPK

• Insulin

• Leptin

• Glucagon

What is the potential benefit of understanding the metabolic effects of caloric restriction?

• Enhancing athletic performance

• Co-opting evolutionary systems for health benefits

• Increasing food production

• Developing new medications

What is the main takeaway regarding the future of longevity science?

• It depends on genetic modification

• It focuses on working smarter with existing biology

• It is primarily about increasing lifespan

• It requires extreme calorie reduction