Pharmacology Quiz: Enzyme Kinetics and Inhibitors

What are the four key pharmacologic equations mentioned in the introduction?

• Volume of distribution, clearance, loading dose, maintenance dose

• Absorption, distribution, metabolism, excretion

• Potency, efficacy, half-life, bioavailability

• Affinity, efficacy, potency, clearance

What happens to the rate of reaction when substrate concentration increases, given a constant number of enzymes?

• The rate fluctuates

• The rate decreases

• The rate remains constant

• The rate increases

What is the relationship between V-max and enzyme concentration?

• V-max is directly proportional to enzyme concentration

• V-max is inversely proportional to enzyme concentration

• V-max is independent of enzyme concentration

• V-max fluctuates with enzyme concentration

What does a low Km value indicate about an enzyme's affinity for its substrate?

• Low affinity

• High affinity

• No affinity

• Variable affinity

In a Lineweaver-Burk plot, what does the x-intercept represent?

• Inverse of substrate concentration

• Inverse of V-max

• Negative inverse of Km

• Negative inverse of enzyme concentration

What does the y-intercept represent in a Lineweaver-Burk plot?

• Inverse of V-max

• Inverse of enzyme concentration

• Inverse of Km

• Inverse of substrate concentration

How does a competitive inhibitor affect the Km and V-max of an enzyme?

• Increases Km, V-max remains unchanged

• Km remains unchanged, decreases V-max

• Decreases Km, increases V-max

• Increases Km, decreases V-max

What is the effect of a non-competitive inhibitor on V-max?

• Increases V-max

• Decreases V-max

• V-max remains unchanged

• V-max fluctuates

Which type of inhibitor can be overcome by increasing substrate concentration?

• Uncompetitive inhibitor

• Allosteric inhibitor

• Competitive inhibitor

• Non-competitive inhibitor

Which of the following is true about non-competitive inhibitors?

• They decrease V-max without affecting Km

• They resemble the substrate

• They bind to the active site

• They increase both V-max and Km