WorksheetsMutation and DNA repair
Total questions: 20
Worksheet time: 11mins
Name
Class
Date
1.
Once a mutation has occurred, it is definitely going to be permanent in the organism.
a)
True
b)
False
2.
A nonsense mutation results in _________.
a)
A truncated protein
b)
A slightly altered polypeptide chain
c)
A shift in the reading frame
d)
The regulatory sequence being altered.
3.
What type of gene do cancer researchers often "turn off" in order to study cancer?
a)
proto-oncogense
b)
oncogenes
c)
constitutive genes
d)
tumor supressor genes
4.
Because some amino acids can be coded for by multiple codons, this type of mutation is possible.
a)
Nonsense Mutation
b)
Missense Mutation
c)
Degenerate Mutation
d)
Silent Mutation
5.
If below is the wild-type DNA sequence, which one shows a point mutation?
5'-ATTCGC-3'
5'-ATTCGC-3'
a)
5' - AATTCGC - 3'
b)
5'- ATCCGC - 3'
c)
5' - ATCGC - 3'
d)
5' - ATTCGC - 3'
6.
A base pair substitution can result in all of the following except __________.
a)
Missense mutation
b)
Frameshift Mutation
c)
Silent Mutation
d)
Nonsense mutation
7.
What kind of mutation is the result of an insertion?
a)
Silent Mutation
b)
Missense mutation
c)
Nonsense mutation
d)
Frameshift mutation
8.
If a nonsense mutation occurred in the gene for the lac repressor, how would it affect the lac operon?
a)
The lac operon would be on all the time
b)
The lac operon would be off all the time
c)
There would be no change in the expression of the lac operon because the repressor does not affect the operon itself.
d)
It would depend on the presence of glucose.
9.
Which of these are not changes to a proto-oncogene that would contribute to the development of cancer?
a)
retroviral insertions
b)
apoptosis
c)
missense mutations
d)
chromosomal translocation
10.
Mutations usually _____________
a)
Are helpful
b)
Are harmful
c)
Are awesome
d)
happen spontaneously
11.
Which type of mutations are heritable
a)
Mutations in somatic cells
b)
Mutations in germ line cells
c)
Mutations in germ line cells and somatic cells are both heritable.
d)
It depends on the specific mutation.
12.
Ultraviolet light often causes which type of mutation?
a)
Missense mutation
b)
Pyrimidine Dimers
c)
Methylated DNA
d)
Cancer
13.
What is the most common DNA repair mechanism
a)
Apoptosis
b)
Nucleotide Excision Repair
c)
Methyl Directed Mismatch Repair
d)
Ames Test
14.
What is a neoplasm?
a)
A cluster of cells with the same missense mutation.
b)
An individual cell that with a missense mutation.
c)
A group of cells that has lost the ability to regulate their growth and division.
d)
A new clump of cells.
15.
Which of these do not contribute to the development of cancer?
a)
Constitutive genes
b)
proto-oncogenes
c)
pyrimidine dimers
d)
carcinogens
16.
A mutation in the promoter could change the amino acid sequence.
a)
True
b)
False
17.
What makes silent mutations possible?
a)
Gene regulation
b)
The degeneracy of the genetic code
c)
Post transcriptional alterations
d)
Frameshifts
18.
If there is a mutation that changes one amino acid to another amino acid that is similar in structure, it is possible that the gene product will still be able to perform its original function.
a)
True
b)
False
19.
What bio molecule do mutations first manifest themselves in?
a)
mRNA
b)
Proteins
c)
DNA
d)
It could be any of these
20.
The gene product is _________
a)
Promoter, Operator, Gene, Terminator
b)
Polypeptide Chain
c)
DNA
d)
Oncogenes
100 %
