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WorksheetsThalassemia & Hemoglobinopathies
Total questions: 10
Worksheet time: 8mins
Name
Class
Date
1.
The principle for hemoglobin electrophoresis is based on which of the following?
a)
Net charge of the hemoglobin molecule
b)
Amount of hemoglobin present
c)
Structure of heme portion
d)
Temperature
2.
Hemoglobin present on electrophoresis for homozygous sickle cell disease?
a)
HbA, S, F, A2
b)
HbS, F, A2
c)
HbA, E, F, A2
d)
HbA, C, F
3.
T/F: Sickle cell disease is negative for Dithionate solubility test.
a)
False
b)
True
4.
Hemoglobin E migrates with which of the following on alkaline electrophoresis?
a)
HbF
b)
HbS & C
c)
HbA2 & C
d)
HbA & F
5.
HbH inclusions are seen when stained with which of the following?
a)
Wright- Giemsa
b)
Prussian Blue
c)
Brilliant Cresyl Blue
d)
Romanowsky
6.
What is the treatment for α-Thalassemia minor?
a)
Splenectomy
b)
Transfusion therapy
c)
Bone marrow transplant
d)
Usually asymptomatic, no treatment
7.
α-Thalassemia most commonly results from which of the following genetic lesions?
a)
Promoter mutation
b)
Gene deletion
c)
Termination codon mutation
d)
Splice site mutation
8.
Why is hydrops fetalis incompatible with life?
a)
Life cannot exist without HbA
b)
Fetal hemoglobin is essential to sustain life after birth
c)
All three normal adult hemoglobins contain α-chains
d)
Lack of embryonic hemoglobins precludes fetal development
9.
Which genotype is correct for β-Thalassemia major?
a)
β/β, β0/β+, β-/β-
b)
βsc/β, β+/β, β0/β0
c)
β+/β-, β-/β-, β-/β0
d)
β0/β0, β0/β+, β+/β+
10.
The single best lab test to distinguish β-Thalassemia minor from α-Thalassemia, IDA, HPFH, and hemoglobinopathies is?
a)
HbA2 levels
b)
Serum iron
c)
Hemoglobin solubility
d)
Heinz body stain
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