Worksheets1.01 Types of Biomed Research
Total questions: 28
Worksheet time: 14mins
Name
Class
Date
1.
Research experiments that use animals as models should be set up using the three R's, which are:
a)
restrict, reduce and reconfigure
b)
reconstruct, recycle and reconfigure
c)
replace, reduce and refine
d)
reuse, redistrubute, and redefine
2.
Which study, performed earlier this century, established that the fourteenth-century Black Plague was spread from rats to humans via fleas?
a)
descriptive
b)
epidemiological
c)
experimental
d)
observational
3.
Which group is often given a placebo or inactive substance when a new medication is tested in biomedical research?
a)
experimental
b)
control
c)
homogenous
d)
descriptive
4.
A major disadvantage of epidemiological studies is that:
a)
they identify patterns in diseases that may be traced to causative factors
b)
ethical considerations may limit their usefulness
c)
considerable human exposure can take place before a toxic effect is detectable
d)
it is difficult to generate sufficiently reliable data
5.
Which type of research method may be conducted on either animals, humans, computer models, or tissue cultures?
a)
clinical research
b)
in vitro research
c)
applied research
d)
basic research
6.
Julio is a researcher and has been assigned to collect statistical data on the Zika virus. What level of research is he working on if his findings will be used to develop a vaccine or new treatment?
a)
basic
b)
applied
c)
clinical
d)
Phase I
7.
The use of mice in biomedical research most frequently occurs at which level?
a)
basic
b)
applied
c)
clinical
d)
phase I
8.
Congress passed the Clinical Laboratory Improvement Amendments in 1988 to ensure the accuracy of diagnostic testing. Under this law, the federal government regulates many aspects of laboratory operation, including:
a)
making sure labels with at least two patient identifiers, such as name and date of birth
b)
the training employees receive and the types and quality of instruments used to analyze samples
c)
making su
9.
Adult stem cells are to be harvested and transplanted into a patient. Where would these cells most likely be found?
a)
in an embryo
b)
in muscle tissue
c)
in human bone marrow
d)
in a clone
10.
Scientists are currently conducting studies in vitro. Where are these studies most likely taking place?
a)
in a petri dish or test tube
b)
in a living organism
c)
in an animal cage
d)
in a computer database
11.
Which level of biomedical research is considered a foundation or "building block" level?
a)
basic
b)
applied
c)
clinical
d)
phase I
12.
Which phase of clinical research is used to determine a drug's interaction with the human system, involves a small number of healthy volunteers, and usually takes around one year to finish?
a)
Phase I
b)
Phase II
c)
Phase III
d)
Phase IV
13.
What area of science studies biological life processes and the causes for disease?
a)
Biomedical Research
b)
Physical Research
c)
Scientific Research
d)
Lifestyle Research
14.
Stan is working with a type of research study with some limitations. This study cannot respond to other functions within a living organism of whole body systems. This type of research can be identified as:
a)
basic
b)
clinical
c)
Phase I
d)
in vitro
15.
Which type of epidemiological study is greatly limited by ethical and legal considerations?
a)
experimental
b)
observational
c)
geographical
d)
descriptive
16.
Which type of study is the human equivalent of animal testing and is administered by providing or withholding a substance to determine its toxic or beneficial effects?
a)
experimental epidemiology
b)
descriptive epidemiology
c)
observational epidemiology
d)
distribution epidemiology
17.
Epidemiology studies may be divided up into three general types:
a)
experimental, descriptive and observational
b)
experimental, comparison and case-controlled
c)
observational, descriptive and case-controlled
d)
observational, retrospective and experimental
18.
Which type of research involves human subjects and is conducted after other forms of research have already taken place?
a)
basic research
b)
applied research
c)
clinical research
d)
toxicity research
19.
Which type of research is directed towards specific objectives and is conducted using animals and other nonanimal models such as computers and tissue cultures?
a)
basic research
b)
applied research
c)
clinical research
d)
descriptive research
20.
Which term best describes the study of disease incidence and its distribution in a population?
a)
comparisons
b)
descriptive
c)
epidemiology
d)
observational
21.
What research method is the best known surrogate for humans in the laboratory?
a)
computer models
b)
mathematical models
c)
nonhuman animal models
d)
in vitro
22.
An experimental medication is being tested on research mice. To obtain the most accurate results, the test should include an experimental group and a/an:
a)
epidemic group
b)
Phase I group
c)
descriptive group
d)
control group
23.
Descriptive epidemiological studies identify:
a)
direct cause and effect
b)
correlations
c)
selection bias
d)
incidence numbers and distribution spread
24.
During which phase of clinical trials is the safety and effectiveness of a medication tested on the greatest number and variety of participants?
a)
Phase I
b)
Phase II
c)
Phase III
d)
Phase IV
25.
What stage of clinical trials involves extensive testing, using around 1,000 - 3,000 subjects, with the overall purpose of determining a drug's efficacy and adverse reactions?
a)
Phase I
b)
Phase II
c)
Phase III
d)
Phase IV
26.
The Clinical Laboratory Improvement Amendments passed in 1988:
a)
monitor patient identifiers on labels
b)
developed technical standards and laboratory practice guidelines
c)
restrict laboratory testing practices
d)
regulate laboratory sites that test only non-human specimens
27.
During biomedical research using animals, a control group was given a placebo. This group will most likely have what type of response?
a)
a positive response
b)
a negative response
c)
no response
d)
a side effect
28.
Chemical, mechanical, and computer simulations are effective research methods but cannot:
a)
replace building blocks
b)
replace laboratory testing on animals
c)
reduce the number of scientists needed
d)
reduce the total time spent on research
100 %
