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WorksheetsBio treatment for schizophrenia
Total questions: 20
Worksheet time: 10mins
Name
Class
Date
1.
Chlorpromazine was found to reduce psychotic symptoms and became the first anti-psychotic in the
a)
1940s
b)
1950s
c)
1960s
d)
1970s
2.
Chlorpromazine is a
a)
dopamine antagonist
b)
dopamine agonist
c)
serotonin antagonist
d)
glutamate agonist
3.
Chlorpromzine does not reduce
a)
hallucinations and delusions
b)
positive symptoms
c)
affective flattening and mutism
d)
though insertion
4.
Chlorpromazine works by blocking dopamine receptors
a)
without activating them
b)
and inhibiting reuptake
c)
and serotonin receptors
d)
which decreases glutamate
5.
The most effective first generation anti-psychotics bind well to which type of dopamine receptor?
a)
D1
b)
D2
c)
D3
d)
D4
6.
Which drugs bind best to D2s?
a)
clozapine and loxapine
b)
olanzapine and risperidone
c)
chlorpromazine and fluphenazine
d)
haloperidol and spiroperidol
7.
What percentage gain no relief from typical anti-psychotics such as chlorpromazine?
a)
20%
b)
30%
c)
40%
d)
50%
8.
First generation anti-psychotics have can lead to extra-pyramidal symptoms such as
a)
dramatic weight gain
b)
drooling
c)
agranulocytosis
d)
tardive dyskinesia
9.
Clozapine is an atypical anti psychotic and it works by blocking dopamine receptors and
a)
reducing dopamine release
b)
blocking NMDA receptors
c)
blocking serotonin receptors
d)
inhibiting reuptake
10.
Clozapine is an atypical antipsychotic - these can be more effective than typicals because they
a)
increase weight gain
b)
reduce negative symptoms as well as positive
c)
reduce glutamate
d)
cause tardive dyskinesia
11.
Which of the following side effects is greatly reduced with atypical anti-psychotics
a)
diabetes
b)
agranulocytosis
c)
tardive dyskinesia
d)
severe weight gain
12.
Clozapine is a very effective drug for people who
a)
do not respond to typical anti-psychotics
b)
have low levels of white blood cells
c)
are homeless
d)
need to lose weight
13.
Clozapine can be dangerous as it can greatly reduce white blood cells leading to a condition called now as it can induce a potentially fatal condition called . Less dangerous but unpleasant side effects include sialorrhea or excessive drooling. Other SGAs which also reduce serotonin, such as the catchily titled M100907, have also been shown to be effective in reducing both positive and negative symptoms with less severe side effects.
a)
agranulocytosis
b)
neuroleptic malignant disorder
c)
dystonia
d)
hyperprolactinaemia
14.
Clozapine can also lead to
a)
excessive drooling
b)
weight loss
c)
mutism
d)
affective flattening
15.
Following a psychotic episode Krishna Patel (2014) says that antipsychotic medication should be initiated
a)
only as a last resort
b)
as soon as possible
c)
if CBT doesn't work
d)
following family therapy
16.
Maintenance doses of anti-psychotics are important as without this, relapse occurs in
a)
60-80% of cases
b)
18-32% of cases
c)
40-50% of cases
d)
32-46% of cases
17.
A maintenance dose should be maintained for at least
a)
12 months following remission
b)
6 months following remission
c)
18 months following remission
d)
2 years following remission
18.
Which of the following is not part of the The Texas Medication Algorithm Project (TMAP) for hard to treat patients:
a)
ECT
b)
combinations of more than one drug
c)
mood stabilisers
d)
surgery
19.
A new third generation of antipsychotics are now being tested, these drugs are
a)
glutamate agonists
b)
dopamine agonists
c)
glutamate antagonists
d)
GABA antagonists
20.
Drug companies can measure the effectiveness of drugs for lowering symptoms using the PANSS which involves
a)
a 20 min interview and rating 10 symptoms on a 5 point scale
b)
a 30 min interview and rating 20 symptoms on a 7 point scale
c)
a 45 min interview and rating 20 symptoms on a 7 point scale
d)
a 45 min interview and rating 30 symptoms on a 7 point scale
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