WorksheetsAnother Bio Explanation of SZ: Genetics
Total questions: 21
Worksheet time: 11mins
The number of genes in the human genome
around 23000
around 230,000
around 2300
around 2, 300,000
Schizophrenia is a heritable condition
true
false
Most people with schizophrenia also have a close relative with schizophrenia
true
false
Research has now found specific genes which cause schizophrenia
true
false
At least ............... chromosomes appear to be implicated in the development of schizophrenia
10
11
12
13
There is mounting evidence to suggest that the following chromosomes are important in the development of schizophrenia
13 and 6.
14 and 5
15 and 3
17 and 8
In 2014, Jessica ................. indicated that as many as 700 genes have been linked to schizophrenia and by now this figure is likely to be in the thousands.
Right
Wright
Write
Wrong
Jessica Wright indicates that as many as ........... genes have been linked to schizophrenia
700
70
1000
1700
Correct name for a gene mutation passed down from parents to their offspring
a germline mutation
acquired mutation
transgenerational mutation
heritable mutation
Gene mutations are not always inherited and can be caused by an environmental factor or an error during cell division, such as a deletion or duplication of a strand of DNA. These mutations are called ...
acquired mutations
environmental mutations
germline mutations
nurtured mutations
Name of the syndrome associated with a large deletion of genes from the 22q11.21 region on chromosome 22 where as many as 25% of people develop schizophrenia.
Di George Syndrome
Van George Syndrome
Di Henry Syndrome
Van Henry Syndrome
Approximate number of genes deleted in Di George Syndrome
20-30
30-40
40-50
50-60
Region of chromosome 22 where genes are deleted in Di George syndrome
22q11.21
11q22.21
21q11.22
22q21.11
Percentage of people with Di George who develop schizophrenia.
2.5%
12.5%
25%
35%
The link with between schizophrenia and Di George may be due to the deletion of a specific gene called ....
COMT
DISC1
PAX1
HOX
The COMT gene may be linked to schizophrenia because it provides instructions for the creation of
an enzyme which breaks down dopamine
receptors sites for dopamine
the production of glutamate
GABA interneurons
The COMT gene may be involved in controlling dopamine levels in the regions such as
the prefrontal cortex
the nucleus accumbens
the temporal lobe
the amygdala
People with an abnormality to the gene Disrupted-in-Schizophrenia 1 or DISC1 are ............... more likely to develop schizophrenia than people without this abnormality.
1.4 times
2.4 times
4 times
5 times
DISC1 codes for the creation of
GABA
dopamine
serotonin
glutamate
DISC1 is related to schizophrenia because it codes for the creation of GABA which controls level of dopamine in the
limbic system
prefrontal cortex
temporal lobe
cerebellum
Offspring of women who became pregnant during the Dutch Winter Famine of 1944, were how many times more likely to develop schizophrenia?
1.4 times more likely
twice as likely
three times more likely
four times more likely
