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WorksheetsComplement
Total questions: 30
Worksheet time: 30mins
The Classical Pathway is activated by what?
IgM binding to two C1 enzymes
Two Fc regions of IgG binding to C1
Attachment of maltose binding lectin to microbe
C3b deposits on the surface of a microbe
Two IgE binding to a single microbe
The Lectin Pathway is activated by what?
Attachment of maltose binding lectin to microbe
Attachment of glucose binding lectin to microbe
Attachment of mannose binding lectin to microbe
C3b deposits on the surface of a microbe
IgE
The Alternative Pathway is activated by what?
IgM binding to two C1 enzymes
Two Fc regions of IgG binding to C1
Attachment of glucose binding lectin to microbe
C3b deposits on the surface of a microbe
Two IgE binding to a single microbe
What is the most abundant complement protein in blood plasma?
C3
C1
C3b
C5
C3b is formed from...
The hydrolysis of C3
Via Factor B
Via C1
Via C3 convertase
C3 convertase
C4b2a
C4b2a3b
C3bBb
C3bBb3b
C3 convertase in the Alternative Pathway
C4b2a
C4b2a3b
C3bBb
C3bBb3b
C3 convertase in the Classical Pathway
C4b2a
C4b2a3b
C3bBb
C3bBb3b
C5 convertase
C4b2a
C4b2a3b
C3bBb
C3bBb3b
C5 convertase in Alternative Pathway
C4b2a
C4b2a3b
C3bBb
C3bBb3b
C5 convertase in Classical Pathway
C4b2a
C4b2a3b
C3bBb
C3bBb3b
Factor B is broken down to form...
Bb
C3b
C4b2a
B2b
C3a, which is cleaved from C3, acts as a/an...
chemokine promoting inflammation
subunit of the C3 convertase
regulatory inhibitor of C3 convertase
allosteric enzyme
What makes up C3 Convertase in the Alternative Pathway?
Bb bound to C3b
Factor B bound to C3b
C4b bound to C2a
Hydrolysis of C3
What makes up C3 Convertase in the Classical Pathway?
Bb bound to C3b
Factor B bound to C3b
C4b bound to C2a
Hydrolysis of C3
What makes up C5 convertase in the Alternative Pathway?
C3bBb bound to C3b
C3b bound to Bb
C3bBb bound to Bb
C4b2b bound to C3b
What makes up C5 convertase in the Classical Pathway?
C4b2a bound to C3b
C4b bound to C2b
C3bBb bound to Bb
C3b2b bound to C3b
These pathways are identical past initial activation.
Lectin Pathway
Classical Pathway
Alternative Pathway
Additional Pathway
The net result of early activation steps in the complement systems are...
the coating of microbes with covalently attached C3b
apoptosis within the microbe
antibody opsonization of microbe
reformation of C3 due to absence stimulus enzymes
This helps to recruit the last protein members of the complement system pathways
C5b
C5a
C9
C6-C9
These pathways have the same last three steps.
Classical Pathway
Alternative Pathway
Lectin Pathway
Additional Pathway
The last recruited members of all three pathways are...
C6-C9
C5-C9
C9
C7-C9
These form the membrane attack complex
C5b + C6-C9
C9
C6-C9
C5-C9
Once this happens a pore is formed in the microbe membrane...
C9 polymerizing
C5b recruiting C6-c9
C5 convertase proteolysis of C5
Dissociation of C6-C9
C5a and C5b are formed through...
Proteolysis of C5 via C5 convertase
Proteolysis of C5 via membrane attack complex
Phosphorylation of C5 via C5 convertase
Proteolysis of C5 convertase via membrane attack complex
This is structurally and functionally similar to C1
Mannose binding lectin
Membrane attack complex
C3 convertase
C3bBb
What enzyme(s) are used to cleave C2 and C4?
Mannose binding lectin
C1
C4b2a complex
C3 convertase
Pathway(s) activated in the absence of an antibody...
Lectin Pathway
Alternative Pathway
Classical Pathway
Additional Pathway
These act as chemokines and induce inflammation
C3a
C4a
C5a
C2a
C6a
Complement phagocytosis is initiated by...
CR1 receptor recognizing C3b coated on microbe
MAC pores
Membrane cofactor protein and C3b on microbe signaling phagocyte
CCR5 receptor recognizing MAC on microbe
