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WorksheetsGeneral and Autonomic Pharmacology
Total questions: 20
Worksheet time: 40mins
Parenteral drug administration
has its rate of drug systemic absorption insensitive to drug solubility in interstitial fluid.
has its rate of systemic drug absorption depends on absorbing capillary membrane surface area.
is less predictable compared to oral administration route.
is not acceptable for unconscious patients.
increases its first pass metabolism.
Most drugs easily cross cell membranes by
filtration through pores.
ionised active diffusion.
ionised passive diffusion.
non-ionised passive diffusion.
pinocytosis.
Volume of distribution determines the
bioavailability of a drug.
dosage interval.
loading dose required to achieve the desired steady-state concentration.
maintenance dose required to achieve the desired steady-state concentration.
time to reach steady state.
The enzyme system responsible for the metabolism of most drugs is most likely
alkaline phosphatase.
creatine kinase.
cytochrome P-450.
HMG-CoA.
P-glycoprotein.
When is the rate of elimination constant regardless of concentration?
During first order elimination
During steady state
During zero order elimination
Rate of elimination is always constant
Rate of elimination is never constant
If clearance increases then half-life will
become zero.
decrease.
increase.
not be determined.
stay the same.
The figure below depicts the dose-response curve when drug X is given alone and when it is given in the presence of a fixed dose of either drug Y or drug Z.
Drug Y has the same ED50 as Drug X.
Drug Y is a competitive antagonist.
Drug Z can be displaced by Drug X.
Action of drug Z can be overcome by increasing the dose of Drug X.
Drug Z is a reversible antagonist.
Which of the following provides information about the variation in sensitivity to a drug within a population studied?
Graded dose-response curve
Maximal efficacy
Potency
Quantal dose-response curve
Therapeutic index
Concerning craniosacral outflow,
it controls “fight-or-flight” responses.
it controls the release of renin from the kidney.
the autonomic ganglion is located near the organ innervated.
the effects tend to be more widespread than the thoralumbar outflow.
the postganglionic fibre releases noradrenaline.
Which of the following statements best drug action at cholinergic transmission?
Naphthylvinylpyridine inhibits the uptake the acetylcholine into the vesicles.
Hemicholinium competes with acetylcholine for binding with receptor.
The release of acetylcholine is inhibited by botulinum toxin.
The synthesis of acetylcholine is inhibited by neostigmine.
Vesamicol disables the degradation of acetylcholine.
Which of the following statements best describes drug action at adrenergic transmission?
Phenylalanine is the initial substrate in the synthesis of noradrenaline.
Cocaine interferes with the storage of noradrenaline.
The binding of noradrenaline with receptor is blocked by atropine.
The transport of dopamine into the vesicles is inhibited by guanethidine.
Amphetamine promotes the release of noradrenaline into the synapse.
The enzyme which is responsible for destruction of noradrenaline in the cytosol of adrenergic neuron is most likely to be
catechol-O-methyl transferase (COMT).
DOPA decarboxylase.
dopamine b-hydroxylase.
monoamine oxidase (MAO).
tyrosine hydroxylase.
Urinary retention due to surgery is effectively treated with
atropine.
bethanacol.
furosemide.
hyoscine.
muscarine.
A 49 year old farmer was taken to the Emergency Department following a contamination to organophosphate insecticide on the farm. Which of the following pharmacotherapy combinations is most likely used to treat the farmer?
Adrenaline and pralidoxime
Atropine and propanolol
Noradrenaline and phentolamine
Pralidoxime and atropine
Propanolol and adrenaline
Bronchodilation is caused by
bethanecol.
ipratropium.
methacholine.
phenoxybenzamine.
timolol.
Which of the following drugs is contraindicated in glaucoma?
Acetazolamide
Acetylcholine
Adrenaline
Amphetamine
Atropine
Sympathomimetic is most likely agent that
depress the activity of the heart.
cause bronchoconstrion.
trigger premature labour.
abolish the local anaesthetic action.
improve urinary retention.
Intravenous adrenaline
displays depressor effect in the presence of propranolol.
is used in the emergency treatment of cardiogenic shock.
is used to improve renal blood flow.
is used in the treatment of anaphylactic shock.
relief nasal congestion.
Prazosin is an advantage over phenoxybenxamine in the control of hypertension because it
causes less tachycardia.
causes 1st dose phenomenon.
increases cardiac output.
it also block β-receptor.
is a reversible antagonist.
Timolol is the b-blocker of choice for glaucoma because it
is cardioselective.
lacks anaesthetic effect.
crosses the cornea.
crosses the blood brain barrier.
exhibits partial agonist property
