Based on scientific literature, the wall will lead to habitat destruction and degradation caused by the construction of the wall, and the roads on both sides of it.

One particular concern is damage to Tamaulipan Thornscrub, an increasingly rare ecosystem, near and around South Texas

Many South Texas organisms depend on this ecosystem, but it's slowly disappearing as cities, farms, and ranches displace the Thornscrub.

The growing living things that depend on it would lose access to some of the last remaining patches in Texas if the wall were built.

A wall would also affect other species Wildflower Zapata and Whiskerbush Cactus.

The ocelot, a small native wildcat listed as an endangered species, has already suffered from severe habitat loss; there are no more than 120 left, in Texas, and scientists worry that the wall would deplete their numbers.

With habitat fragmentation, the wall could cut off ocelot and black bear populations in Texas and Mexico from other members of their species; therefore, leaving some populations too small to persist.

Because the wall will probably not be built in the flood plain of the Rio Grande, it will have to be set back from the river; this has the potential to damage the following circumstances: valuable forest ecosystem, organisms that need to get to the river, people from accessing wildlife refuges, and ecotourism.

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