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WorksheetsPharmacology - 5. Sympathomimetics
Total questions: 8
Worksheet time: 4mins
Which of the following drugs has highest affinity for beta 2-receptors:
Ephedrine
Epinephrine
Isoproterenol
Norepinephrine
What happens to the selectivity as the number of carbons increases on the catecholamine’s nitrogen group?
Shifts from alpha-1 to more beta-2
Shifts from beta-2 to more alpha-1
No change in the selectivity of the molecule
Becomes a heavier molecule and therefore we can charge more money for it
What is the signaling pathway for alpha-1?
Gi signaling leading to decreased cAMP
Gs signaling leading to increased cAMP
Gq signaling leading to increased PLC, IP3, DAG, PIP2, and calcium
Gq signaling leading to decreased cAMP
Which drug is a long-acting beta-2 agonist used in conjunction with corticosteroids for the treatment of asthma?
Albuterol
Formoterol
Isoproterenol
Epinephrine
What is diastolic blood pressure determined by?
Total peripheral resistance
Cardiac output
Beta 1 receptors
Heart rate
What causes Norepinephrine’s reflex bradycardia
Stimulation of the beta 1 receptor leading to increased heart rate
Stimulation of the beta 2 receptor leading to lower diastolic blood pressure
Stimulation of the alpha 1 receptor leading to higher diastolic blood pressure
Stimulation of the alpha 2 receptor inhibiting norepinephrine release
AB has overdosed on cocaine. What physiological effect has cocaine had on AB’s synapse?
Cocaine has caused her NET to reverse its transport
Acts as a substrate for NET
Acts as a blocker of NET
Binds to VMAT
Salmeterol is a reasonable as monotherapy for the treatment of asthma
True
False
