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Microbiology credit III

Total questions: 78

Worksheet time: 39mins

Name
Class
Date
1.

Which of the following methods is used to determine the MIC?

a)

E-test

b)

Kirby Bauer

c)

Thayer Martin method

d)

Disc diffusion

2.

An natibiogram can best be defined as?

a)

The time reuired to kill a bacterium by a particular antibiotic

b)

The antibiotics to which a bacterium is susceptible

c)

The overall suscpetibillity profile of a bacterium

d)

The antibiotics to which a bacterium is resistant

3.

Tetracyclins inhibit bacterial protein synthesis through binding to ..... bacterial ribosome subunits and they are .... antibiotics??

a)

30s, narrow spectrum

b)

30s, broad spectrum

c)

50s, narrow spectrum

d)

50, broad spectrum

4.

which of the following is example of natural resistance?

a)

Penicillin resistance in Streptococcus pneuomiae

b)

Resistance to cephalosporins is enterococcus

c)

MBL enzymes in E. coli

d)

All of the above

5.

Which of the following is beta-lactamase inhibiting compound?

a)

Clavuric acid

b)

Tazobactam

c)

Sulbactam

d)

All of the above

6.

Which of the following antibiotics might be immedialty rejected as an option to test infections caused by bacteriodes fragillis

a)

Tetracyclines

b)

Aminoglycosides

7.

How does Aminoglycosides work?

a)

Inhibition of protein synthesis

b)

Inhibition of folic acid pathway

c)

Inhibtion of RNA synthesis

d)

Binding with PBPs

8.

Which one of these inhibits folic acid pathway?

a)

Sulfonamide

b)

Chloramfenicol

c)

Vancomycin

d)

Rifampin

9.

Inhibts RNA synthesis?

a)

Rifampin

b)

Carbapenems

c)

Vancomycin

d)

Sulfonamide

10.

Binds with PBPs

a)

Carbapenems

b)

Chloramphenicol

c)

Sulfonamide

d)

Vancomycin

11.

Inhibits protein synthesis

a)

Chloramfenicol

b)

Vancomycin

c)

Rifampin

d)

Solfonamide

12.

Inhibits cell wall synthesis?

a)

Vancomycin

b)

Sulfonamide

c)

Carbapenem

d)

Rifampin

13.

Of the following Beta-lactam resistant bacteria, which would most likely be considered sucpetible by the addition of Calvulanic acid with a beta-lactam?

a)

Methicillin resistant Staphylococcus aureus

b)

Mycoplasma pneumoniae

c)

Beta-lactam producing Haemphilus influenzae

d)

Mycobacterium Tuberculosis

14.

Bacterial cell wall synthesis inhibitors inlude all of the following, EXCEPT?

a)

Linazoid

b)

Carbapenems

c)

Monobactams Bactracin

d)

Vancomycin

15.

Patient with pneumoniae is treated empirically with imipenem. the lab results shows that the infection is caused by Klebsiella pneumoniae ESBL-producing strain.

a)

The therapy can be continued with imipenem

b)

Imipenem must be replaced by a 4th gen- cephalosporin

c)

Imipenem must be replaced by vancomycin

d)

Imipenem must be replaced by a non-beta-lactam antibiotic

16.

Antimicrobial agent which can be active vs VRSA/MRSA strains is?

a)

carbapenem

b)

Linezoid

c)

4th gen- cephalosporin

d)

Oxacillin

17.

Penicillin resistance in Streptococcus pneumoniae

a)

is caused by beta-lactamase

b)

is associated with production of penicllinase

c)

Is the result of modifications in PBPs

d)

Is the result of changes in cell membrane permeability

18.

Methicillin resistant Staphylococcus Aureus strains are resistant to methicillin because?

a)

They have acquired a plasmid encoding Beta-lactamase

b)

They acquired penicllin binding protein with low affinity to methicllin

c)

they modify the penicllin binding protein with an enzyme from a plasmid

d)

they are accumulating point mutations in penicillin binding proteins

19.

Altered PBPs

a)

Imipenem

b)

Erythromycin

c)

Gentamicin

20.

antimicrobial agent, that cause methylation of 23s RNA

a)

Erythromycin

b)

Imipenem

c)

Gentamicin

21.

Production of modifying enzymes

a)

Gentamicin

b)

Ertyhromycin

c)

Impenem

d)

Trimethoprim

22.

Altered metabolic pathway

a)

Trimethoprim

b)

Imipenem

c)

Ertyhromycin

d)

Gentamicin

23.

What does VRE stand for?

a)

Vancomycin Resistant Enterbacter

b)

Vanco resistance enterococcus

c)

Very Reluctant Ether

24.

What does HLAR stand for?

a)

high level aminoglycoside resistance

b)

Highly Amino nucleic acid reprival

25.

Extended spectrum beta-lactamase are usually produced by

a)

Enterobacteriaeae

b)

Neisseria and Hemophilus

c)

Enterococcus faecalis and Enterococcus T.....

26.

Which of the following pairs is mismatched?

a)

MRSA - PBP2s

b)

HLAR - beta-lactamases

27.

Which of the following has a narrow spectrum of activity?

a)

ciprofloxacin

b)

Tetracycline

c)

Vancomycin

d)

Erythromycin

28.

The antibiotics erythromycin, azithromycin, and clarithromycin all belong to the group known as:

a)

aminoglycosides

b)

Macrolides

c)

Tetracyclines

d)

Cehpalosporins

29.

Which of the following pairs is mismatched?

a)

ampicillin - haemophilus influenzae

b)

Tetracyclines - staphylococcus aureus

c)

Ampicillin - pseudomonas aeruginosa

30.

Metronidazol is usually used to treat infections caused by:

a)

NRSA

b)

E. coli

c)

Anaerboic bacteria

d)

Gram positive bacteria

31.

Tetracyclines are effective against which of the following?

a)

Gram pos bacteria

b)

Gram neg bacteria

c)

.... intracellular bacteria

d)

All of the above

32.

Antifungal agents, inhibitor of glucan synthesis?

a)

Cospofungin

b)

Nikkomycin

c)

Nystatin

d)

Voriconazole

33.

Antifungal agents, inhibitor of chitin synthesis?

a)

Nikkomycin

b)

Voricenazole

c)

Nystatin

d)

Flucytosine

34.

Antifungal agents, inhibitor of ergosterol synthesis?

a)

Voriconazole

b)

Nikkomycin

c)

Caspofungin

d)

Flucytosine

35.

Antifungal agents, direct interactions with ergosterol?

a)

Nystatin

b)

Nikkomycin

c)

Cospofungin

d)

Voriconazole

36.

antifungal agents, inhibitor of nucleic acid synthesis?

a)

Flucytosine

b)

Nikkomycin

c)

Cospofungin

d)

Nystatin

37.

Which of the following shows synergistic characteristics for fungal infections when combined with amphotericin B?

a)

Metronidazole

b)

Clindamycin

c)

Aztreonam

d)

Flucytosine

38.

1-4, which one of these infectious agents are most resistant to sterilization?

a)

Prions, Bacillus Anthracis, Salmonella, M. tuberculosis

b)

Bacillus anthracis, salmonella, M, tuberculosis, Prions

c)

Prions, Bacillus anthracis, M. tuberculosis, Salmonella

39.

Which of the following can inactivate prions?

a)

Filtration

b)

Gamma radiation

c)

121 C for 15 min

d)

None of the above

40.

Which of the following heavy metals is used commonly as an antimicrobial agent

a)

mercury

b)

Silver

c)

chorine

41.

chemicals, Sterilants?

a)

Ethylene oxide

b)

Glutaraldehyde

c)

Triclosan

d)

Iodine

42.

chemicals, phenocolics

a)

Triclosan

b)

Ethylene oxide

c)

chlorhexidine

43.

Chemicals, halogens

a)

Iodine, chloramine

b)

Glutaraldehyde, Ethylene oxide

c)

Triclosan

44.

Match the following terms, Hydrogen peroxide?

a)

Plasma sterilization

b)

Tyndallization

c)

HEPA

d)

Autoclave

45.

Match the following terms, triple pasteurization?

a)

Plasma sterilization

b)

Tyndallization

c)

Autoclave

d)

HEPA

46.

Match the following term, Steam under pressure?

a)

Autoclave

b)

HEPA

c)

Tyndallization

47.

Filtration??

a)

Tyndallization

b)

Autoclave

c)

HEPA

d)

Cold sterilization

48.

Ethylene oxide?

a)

Cold sterilization

b)

Autoclave

c)

Plasma sterilization

d)

Tyndallization

49.

What is HAART?

a)

Highly active antiretroviral therapy

b)

Highly Adenosine-active retrotissue

50.

Which of the following antibiotics might be immedialty rejected as an option to treat a disease caused by E. Coli?

a)

Ampicillins

b)

tetracyclines

c)

Glycopeptides

d)

Cephalosporins

51.

Adverse side effects such as nephrotoxicity and Ototoxicity are usually associated with?

a)

Tetracyclines

b)

Macrolides

c)

Aminoglycosides

d)

Cephalosporins

52.

Penicillin resistance of Streptococcus pneumoniae is caused by?

a)

mutations in gene encoding penicillin-binding proteins gradually increasing resistance

b)

PLasmid encoded Beta-lactamase genes

c)

Changing in the cell wall porins

53.

Protein synthesis inhibitors inlude all of the following except?

a)

Tetracyclines

b)

Macrolides

c)

Aminoglycosides

d)

Rifampin

54.

Each of the following is true for MRSA strains except:

a)

Are resistant to all beta-lactam antibiotics

b)

Posess altered PBP

c)

Can be treated by beta-lactam/beta-lactamase inhibitor combinations

d)

Are usually resistant to multiple antimicrobial agents

55.

Extended spectrum beta-lactamases are usaully produced by?

a)

S. aureus and S. pneumoniae

b)

E. coli and Klebsiella

c)

Neisseria and Haemophilus

d)

Enterococcus faecalis and enterococcus fascium

56.

Which combinations of antibiotics is commonly used to achieve a synergistic effect ?

a)

penicllin and cafotaxine

b)

Sulfonamide and trimethaprim

c)

Erythromycin and tetracyclin

d)

Gentamycin and chloramphenicol

57.

Sulbactam

a)

Inhibits LPS synthesis

b)

Is active only against mycobacteria

c)

Inhibits Beta-lactamases

d)

Is active only against strict anaerobic bacteria

58.

According to the mechanism of action which of the follwoing pairs is mismatched?

a)

Lincosamides and macrolides

b)

Ampicillin and imipenem

c)

Flurochinolones and chloramphenicol

d)

Tetracyclines and aminoglicosides

59.

Activity of the following beta-lactamases can be inhibited by clavulanic acid except?

a)

ESBLs

b)

TEM and SHV beta-lactamases

c)

S. aureus penicilinases

d)

Carbapenemases

60.

S. aureus is resistant to methicillin, which of the following would be considered active?

a)

Vancomycin

b)

Generation cephalosporins

c)

Aztreonam

d)

Amoxicillin-clavulanic acid

61.

The antibiotics amikacin, streptomycin, and gentamicin all belong to the group known as:

a)

aminoglycosides

b)

macrolides

c)

tetracyclines

d)

cephalosporins

62.

Which of the following sets of antibiotics has the most related targets?

a)

cephalosporins, macrolides, trimethoprim

b)

vancomycin, bactarcin, riframpin

c)

aminoglycosides, tetracycline, macrolides

d)

sulfonamides, metronidazole, monobactams

63.

What is the mechanism of action of voriconazole?

a)

it interacts with ergosterol in the cell membrane

b)

it inhibits ergosterol biosynthesis

c)

it inhibits microtubular function

d)

it inhibits protein synthesis

64.

The drug used to treat infection caused by Dermatopyhtes is:

a)

Griseofulvin

b)

ketoconazloe

c)

caspofungin

d)

amphotericin B

65.

The new antifungal drug - Caspofungin, blocks ..... synthesis

a)

Ergosterol

b)

Lanosterol

c)

Squalene

d)

Beta-glucans

66.

Which of the following is an example of topical antifungal agent:

a)

Nystatin

b)

Flucytosine

c)

Amphotericin B

d)

Fluconazole

67.

Household bleach consists of 5% .....

a)

Ethanol

b)

Chlorhexidine

c)

Sodium hydrochloride

68.

Penicillin G and methicillin are both?

a)

Broad spectrum antibiotics

b)

Narrow spectrum antibiotics

69.

Which antibiotics are not recommended during pregnancy?

a)

Ampicillins

b)

Macroides

c)

Fluroquinoiones

d)

Cephalosporins

70.

Bacterial cell wall synthesis inhibitors include all of the following?

a)

Monobactams

b)

Bacitracin

c)

Vancomycin

d)

Carbapenems

e)

Syneroid

71.

A combination of clavulanic acid with amoxicillin can be used to treat infection caused by?

a)

Penicillin resistant Streptococcus pneumoniae

b)

Beta-lactamase Haemophilus influenza

c)

Carbamenemase-producing Klebsiella pneumoniae

d)

MRSA

72.

Which of the following antibiotics are recommended to treat infections caused by obligate anaerboic bacteria?

a)

gentamicin

b)

Metronidazole

c)

Isoniazid

d)

Bacitracin

73.

Extended-spectrum-beta-lactamases are produced by:

a)

Staphylococcus aureus and Streptococcus pneumoniae

b)

E. Coli and Klebisella pneumoniae

c)

Neissera and Haemophilus

d)

Enterococcus faecalis and Enterococcus faecium

74.

in 2008(ceftobiprol) and 2010(ceftaroline) - the first 5th generation cephalosporins were introduced into marked to treat infections caused especially by:

a)

Methicillin resistant S. aureus

b)

Multidrug resistant M. tuberculosis

c)

Campylobacter jejuni

d)

Costridium difficile

75.

Which of the following methods is used to determined a MIC?

a)

E-test

b)

Kirby Bauer

c)

Thayer-Martin

d)

Disc diffusion

76.

Pneumonia caused by Mycoplasma pneumoniae was diagnosed in a year 2-year old boy. Which of the following antibiotics are recommended in this infection?

a)

Tetracyclines

b)

Penicillins

c)

Glycopeptides

d)

Macrolides

77.

Which of the following is an example of natural resistance?

a)

Resistance to pencillin in Streptococcuc pyogenes

b)

Methicillin resistance in Staphylococcus aureus

c)

resistance to cephalosporins in Listeria monocytogenes

d)

resistance to vancomycin in Enterococcus spp.

78.

Which of the following statements about aminoglycosides is FALSe?

a)

Are ineffective against anaerobic bacteria

b)

Are recommoneded drugs to treat Chlamydia and Ricksettia infections

c)

Bind with 30s of ribosome subunit

d)

Are bactericidal

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