An antibody is a:

Which of the following cell types is responsible for antibody production?

Which of the following provide defense against viral infections?

Which of the following cells in a granulocyte?

Immunity that is a result of an actual infection?

A substance capable of raising the body temperature is:

When an organ or tissue is transplanted between genetically different individuals from the same species it is called an:

Which of the following is a systemic autoimmune disease?

Which is the following is NOT part of the second line of defense?

Enzymes that attack the peptidoglycan layer of bacteria and are present in perspirations, nasal secretions, saliva and tears?

Delayed hypersensitivity is a result of:

MHC

· Organism’s self-antigens are located on the cell membrane and are unique for each individual—except for identical twins with the same genetic code

· These antigen molecules are coded by a group of genes located on chromosome __—forming the MHC

· The MHC plays a major role in the immune system by recognizing self-antigens

· Multigene complex composed of three subgroups: Class I, class II, class III

· Tissue and organ transplantation

· To be successful, as many MHC molecules as possible must match to avoid rejection

§ Most common

§ Local or systemic

§ Involves airway obstruction

§ IgE bind to basophils and mast cells—release histamine

§ Examples eczema, rhinitis (hay fever), asthma, food allergies, drug allergies and anaphylactic reactions

§ Cytotoxic hypersensitivity

§ All type II reactions involve IgG or IgM antibodies

§ Damage caused is localized to a particular tissue or cell type.

§ Examples: Hemolytic disease of newborn, Goodpasture’s Syndrome, Autoimmune hemolytic anemia (coomb’s test positive), Immune Mediated neutropenia

§ Immune complex hypersensitivity reactions

§ Found in certain autoimmune diseases

§ Soluble antigens combine with antibodies to produce free-floating complexes and then deposit in the basement membranes causing the reaction

§ Examples: serum sickness, rheumatoid arthritis

§ Delayed hypersensitivity, takes more than 24 hours and occurs when antigen reacts with antigen specific lymphocytes that release inflammatory substances.

§ These are cell-mediated reactions and part of cell-mediated immunity causing release of chemical mediators such as lymphokines

§ Examples: contact dermatitis and temporal arteritis