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WorksheetsBio12EnglishBiomarkersOncology
Total questions: 10
Worksheet time: 5mins
First hit and second hit on a tumor suppressor gene may be due to:
Single point mutation, deletion, hypermethylation of gene promoter
Histone acetylation and methylation in H3-K4
Hypomethylation at the promoter level
Gene amplification
What is the error rate of the epigenetic signature in inheritance of DNA methylation?
4%
20%
0.001%
0.1%
Why epigenetic biomarkers may be useful in diagnostic assays aimed to early detect cancer?
Epigenetic aberrations are usually early events in the carcinogenesis process
Epigenetic aberrations are late events in the carcinogenesis process
Epigenetic aberrations are difficult to evaluate and cannot be useful in diagnostic procedure
Epigenetic aberrations such as DNA methylation and histone modifications occur immediately after a mutation event has taken place
The mortality rate of oral squamous cell carcinoma within 5 years is?
50%
1%
100%
5%
Oral squamous cell carcinoma is usually very aggressive: one reason is:
2/3 of cases are diagnosed in an advance stage (III-IV)
Mostly all these tumors give brain metastasis
Mostly all these tumors are diagnosed on stage I-II
No treatment of these tumors has been developed due to their rarity
What position does Head and neck squamous cell carcinoma have on the top hit?
6th
1st
20th
10th
Which of the following genes is found to be mutated in OSCC in more than 70% of cases?
TP53
TP63
KRAS
BRCA1
May the methylation pattern of a set of 13 genes be useful to early diagnose OSCC?
Yes, the aberrations of DNA methylation level of a panel of 13 genes has been described to correctly diagnose OSCC from oral brushing
No, only the mutation analysis of oral tissue may identify OSCC
No, the methylation pattern in oral mucosa does not change between normal and tumor tissue
No, alterations in the DNA methylation level of a set of 13 genes was detected only in advanced OSCC
May the DNA methylation pattern of a set of 13 genes be useful to predict recurrence in OSCC?
Yes, an altered methylation pattern in regenerative area after surgical resection during follow up may identify those patients who will develop a recurrence
No, the DNA methylation in patients surgically treated for an OSCC is always altered during follow up
No, oral brushing is not possible in patients surgically treated for an OSCC during follow up because it is an invasive technique not well tolerated
No, DNA methylation does not change during follow up in patients with OSCC
Which is the tumor with the highest somatic mutation frequency/Mbase?
Melanoma
Thyroid cancer
Ewing sarcoma
Medulloblastoma
