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WorksheetsInnate immunity
Total questions: 15
Worksheet time: 8mins
Select the DAMPS
LPS
Peptidoglycan
HMGB1
HSPs
PRR are expressed in all of the following EXCEPT:
Macrophages
Monocytes
B cell
epithelial cells
Neutrophils
The following sequence is correct :
LPS (toxin A) — MD2– TLR2
LPS (toxin A) — CD14– TLR4 — MD2
LPS (toxin A) — MD2—TLR4 — CD14
All TLRs signal through MyD88 to form :
IL-3
IL-4
NF-kB
All TLRs signal through MyD88 EXCEPT:
TLR4
TLR3
TLR2
TLR88
TLR3 signal through :
TRIF
MYD88
TNF
Inflamasome formation
TRIF will activate the following
IL-1
IL-6
IRF3 which will stimulate gene to form type one interferon
TNF
C- type lectin family receptors recognize :
Carbohydrates
Lipids
Amino acids
c-type lectin family :
Nucleic acid receptors
Mannose receptor
Dectin receptors
NOD1 And NOD2 respond to
Lipids
Amino acids
Bacterial cell wall peptidoglycan
LPS
Inflammasome which is activated by NLRP generate active forms of
IL-88
IL-18
IL-1a
IL-1b
To reduce pain in gout we give
Agonist for NLRP
Antagonist for NLRP
Agonist for TLR
True about RIG like receptors
Recognize viral RNA
Can’t differentiate between cell ss RNA and viral ss RNA
Can recognize only viral ss RNA
They respond to Viral nucleic acid by produce type one interferons
TLR , RLR, NLR can stimulate TNF gene by activating
MyD88–> NF-kB
TRIF
Type one interferon
TNF can mediate
Cell death
Cell proliferation
Acute inflammatory response
Suppress inflammation
