When an action potetial spread over the terminal, these channel open and allow K⁺ ions to diffuse from the synaptic space to the interior of the nerve terminal

Opening the acetylcholine -gated channels is to allow large number of Ca²⁺ ions to pour to the inside of the fiber

The acetylcholine is destroy by the enzyme acetylcholinesterase, which is attach mainly to spongy layer of the fine connective tissue

A large amount of acetylcholine diffuses out of the synaptic space and then no longer available to act on the muscle fiber membrane

The sudden increase in nerve membrane potential is normally sufficient to initate more and more Na⁺ channel opening

The effect of Botulinum Toxin, increase the quantitiy of acetylcholine release by the nerve terminals

Neostigmin and Phyostigmine known as a drugs that inactive acetylcholine

Neostigmin works in the synaps so the acetylcholine no longer hydrolyzes

T-tubule communicate the outside of the cell membrane and deep in the muscle fiber in the Sarcoplasmic Reticulum

The action potential of the T-Tubule causes current flow into the sarcoplasmic reticulum

Once the K⁺ ions have been release from the sarcoplasmic reticulum and diffuse, muscle contraction continue

If the contraction continue, a series of the pottasium pulse initiated to had a continouos series of repetitive action potential

Nicotine works as same as the acetylcholine, it works by causing loaclized areas of depolarization of the muscle fiber membrane at the motor end plate where the acetylcholinesterase are located.

Curariform Drugs can prevent passage of impulses from the nerve endinm unto the muscle