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Worksheets

Affective Disorders (Mood Disorders)

Total questions: 40

Worksheet time: 20mins

Name
Class
Date
1.

Which of the following neurotransmitters is found to be predominantly low for a person who is depressed?

a)

5 HT

b)

Dopa

c)

NE

d)

Ach

2.

Tricyclic antidepressants are:

a)

Highly SSRI

b)

MAOi

c)

Selective norepinephrine reuptake inhibitors

d)

Mixed norepinephrine and serotonin reuptake inhibitors

3.

Indicate an effective antidepressant with minimal autonomic toxicity:

a)

Amitrityline

b)

Fluoxetine

c)

Doxepin

d)

Imipramine

4.

A highly selective serotonin re-uptake inhibitor is:

a)

Sertaline

b)

Paroxetine

c)

Fluoxetine

d)

All answers are correct

5.

Valproic acid is used for:

a)

Psychosis

b)

Bipolar

c)

Depression

d)

Fever

6.

The principal mechanism of action of antidepressant agents is:

a)

Stabilization of dopamine and beta-adrenergic receptors

b)

Inhibition of the storage of serotonin and epinephrine in the vesicles of presynaptic nerve endings

c)

Blocking epinephrine or serotonin reuptake pumps

d)

Stimulation of alfa2-norepinephrine receptors

7.

Which of the following features do MAO inhibitors and tricyclic antidepressants have in common?

a)

Act postsynaptically to produce their effect

b)

Can precipitate hypotensive crises if certain foods are ingested

c)

Increase levels of catecholamines

d)

Are useful for the manic phase of bipolar disorder

8.

All of the following adverse effects are associated with lithium treatment, except

a)

Extrapyramidal effects

b)

Thyroid enlargement

c)

Nephrogenic diabetes insipidus

9.

The blockade of which type of Monoamine Oxidase might be more selective for depression?

a)

MAO-A

b)

MAO-B

c)

Both MAO-A and MAO-B

d)

MAO-C

10.

The irreversible MAO inhibitors have a very high risk of developing:

a)

Respiratory depression

b)

Cardiovascular collapse and CNS depression

c)

Hypertensive reactions to tyramine ingested in food

d)

Potentially fatal agranulocytosis

11.

The principal mechanism of action of antidepressant agents is:

a)

Stabilization of dopamine and beta-adrenergic receptors

b)

Inhibition of the storage of serotonin and epinephrine in the vesicles of presynaptic nerve endings

c)

Blocking epinephrine or serotonin reuptake pumps

d)

Stimulation of alfa2-norepinephrine receptors

12.

Which of the following agents is related to tricyclic antidepressants?

a)

Nefazodon

b)

Amitriptyline

c)

Fluoxetine

d)

Isocarboxazid

13.

Which of the following antidepressant agents is a selective inhibitor of norepinephrine reuptake?

a)

Imipramine

b)

Maprotiline

c)

Amitriptyline

d)

Doxepin

14.

Indicate the irreversible MAO inhibitor, which is a hydrazide derivative:

a)

Moclobemide

b)

Selegiline

c)

Clorgyline

d)

Phenelzine

15.

Which of the following antidepressants is a selective short-acting MAO-A inhibitor?

a)

Maprotiline

b)

Amitriptyline

c)

Moclobemide

d)

Selegiline

16.

Monoamine Oxidase A:

a)

Is responsible for norepinephrine, serotonin, and tyramine metabolism

b)

Is more selective for dopamine

c)

Metabolizes norepinephrine and dopamine

d)

Deaminates dopamine and serotonin

17.

Which synapses are mainly involved in depression?

a)

Dopaminergic synapses

b)

Serotoninergic synapses

c)

Cholinergic synapses

d)

All answers are correct

18.

The blockade of which type of Monoamine Oxidase might be more selective for depression?

a)

MAO-A

b)

MAO-B

c)

Both MAO-A and MAO-B

d)

MAO-C

19.

The irreversible MAO inhibitors have a very high risk of developing:

a)

Respiratory depression

b)

Cardiovascular collapse and CNS depression

c)

Hypertensive reactions to tyramine ingested in food

d)

Potentially fatal agranulocytosis

20.

The most dangerous pharmacodynamic interaction is between MAO inhibitors and _______

a)

SSRI

b)

Tricyclics

c)

Sympathomimetics

d)

All answers are correct

21.

The therapeutic response to antidepressant drugs is usually over a period of:

a)

2-3 days

b)

2-8 weeks

c)

24 hours

d)

2-3 month

22.

Which of the following features do MAO inhibitors and tricyclic antidepressants have in common?

a)

Act postsynaptically to produce their effect

b)

Can precipitate hypotensive crises if certain foods are ingested

c)

Increase levels of catecholamines

d)

Are useful for the manic phase of bipolar disorder

23.

Tricyclic antidepressants are:

a)

Highly SSRI

b)

MAOi

c)

Selective norepinephrine reuptake inhibitors

d)

Mixed norepinephrine and serotonin reuptake inhibitors

24.

Indicate an effective antidepressant with minimal autonomic toxicity:

a)

Amitrityline

b)

Fluoxetine

c)

Imipramine

d)

Doxepin

25.

A highly selective serotonin re-uptake inhibitor is:

a)

Sertaline

b)

Paroxetine

c)

Fluoxetine

d)

All answers are correct

26.

Valproic acid is used for:

a)

Psychosis

b)

Depression

c)

Bipolar

d)

Fever

27.

Tricyclics elevate mood in normal individuals

a)

True

b)

False

28.

Tertiary Amine Tricyclics

a)

Amitriptyline

b)

Amoxapine

c)

Aprotiline

d)

Nortriptyline

29.

True about tertiary amine

a)

Primarily Block Dopamine

b)

More likely to induce psychosis

c)

Primarily block NE

d)

Primarily block serotonin uptake

30.

Responsible for the inactivation of any serotonin or NE that may leak out of the presynaptic vesicles

a)

MOA-A

b)

MOA-B

31.

Responsible for the metabolism of dopamine

a)

MOA-A

b)

MOA-B

32.

Prozac:

a)

A.Fluoxetine

b)

B.Sertraline

c)

C.SSRI

d)

D.SSRN

e)

D.A&C

33.

Reversible MAOi

a)

Clorgyline

b)

Phenelzine

34.

Irreversible MAOi

a)

Clorgyline

b)

Phenelzine

35.

Antimanic agent EXCEPT

a)

Lithium

b)

Carbamazepine

c)

Lamotrigine

d)

Topiramate

e)

All answers are correct

36.

Selective MAO-B:

a)

Clorgyline

b)

Phenelzine

c)

NONE

37.

Nonselective MAO-B

a)

Clorgyline

b)

Phenelzine

38.

PRIME-MD score for Moderately severe depression:

a)

14

b)

11

c)

17

d)

20

39.

"May be agitated or have movement retardation" belongs to what state of Bipolar disorder?

a)

Manic

b)

Depressive

40.

"A decrease in a need for sleep" belongs to what state of Bipolar disorder?

a)

Manic

b)

Depressive