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WorksheetsMedicinal Chemistry-III
Total questions: 10
Worksheet time: 6mins
Which of the following drugs is a gastric acid resistant?
Penicillin G
Penicillin V
Carbenicillin
Procain penicillin
Infer the mechanism of penicillins’ antibacterial effect is
Inhibition of transpeptidation in the bacterial cell wall
Inhibition of beta-lactamase in the bacterial cell
Activation of endogenous proteases, that destroy bacterial cell wall
Activation of endogenous phospholipases, which leads to alteration of cell membrane permeability
What role does the acetoxy group at the 3-position of cephalosporins have in enhancing antibacterial activity?
It acts as a steric shield and masks enzymatic attack at the β-lactam ring
It acts as a good leaving group when the β-lactam ring is opened.
It takes part in a transesterification reaction with the carboxylic acid group at position 4.
It increases the reactivity of the β-lactam ring by neighbouring group participation
The following structure (cefalexin) is a first generation cephalosporin.
Which of the following statements is true for the methyl substituent at position 3?
It is a good leaving group
It is generally good for activity
It acts as a steric shield
It is good for oral activity
What is the target for Clavulanic acid?
The transpeptidase enzyme
L-ala racemase
β-lactamase
Penicillin acylase
which of the betalactum has only one ring structure
aztreonam
carbapenam
cephalosporin
pencillin
Which of the following antibiotics is a tetracycline?
Chloramphenicol
Doxycycline
Streptomycin
Pencillin
Aminoglycosides have the following unwanted effects:
Pancytopenia
Hepatotoxicity
Ototoxicity
Irritation of gastrointestinal mucosa
C-12 position is a part of the keto-enol system in
macrolide antibiotics
penicillins
tetracyclines
aminoglycoside antibiotics
Cephalosporin C on hydrolysis will not give
6 APA
Acetic acid
Pencillamine
Dipeptide
