WorksheetsCell Signaling SMBB 4193 Quiz 2
Total questions: 15
Worksheet time: 8mins
1.What do these descriptions refer to?
*A small subpopulation within the tumour
*Possess similar properties to normal stem cells
*Overexpresses a set of stem cell genes
Pluripotent stem cells
Embryonic stem cells
Cancer stem cells
Epithelial cells
what is the role of a transcription factor?
essential for the regulation of gene expression
differentiate into any cell lineage of the body, and their potential for indefinite self-renewal.
a defined cell population derived from the inner cell mass of the cleavage-stage embryo
plays vital role in cellular proliferation, cellular movement, establishment of cell polarity & in stem cell maintenance
Which of these are tumor suppressor genes?
I) OCT4 II) p53 III) NANOG IV) Rb
I and II
II and III
II and IV
All the above
What type of mutation does the figure represent?
Insertion
Duplication
Inversion
Translocation
Name THREE (3) common point mutations
What are the 1st and 5th events in the cancer hallmark?
1st:sustaining proliferation signalling & 5th:angiogenesis
1st:evading growth suppressors & 5th:angiogenesis
1st:evading growth suppressors & 5th:resisting cell death
1st:activating invasion n metastasis & 5th:enabling replicative immortality
Name THREE (3) embryonic stem cell signalling pathways.
The TWO (2) components below have important functions in the (a) signalling pathway.
*SMO
*PATCH
The (a) is known as the genetic gatekeeper in the Wnt-Beta Catenin signaling pathway
The (a) component in the Notch signalling pathway can induce proliferation and inhibit differentiation under abnormal condition.
Which of these are important components in the Notch signalling pathway?
I) PUMA IV) CSL
II) NICD V) MAML
III) Notch 1 VI) Destruction complex
I, II and III and VI
I, II and VI
II, III, IV and V
All the above
II, III, IV and VI
What happens here (3rd step)???
nuclear collapse
continued blebbing
lysis of apoptotic bodies
chromatin condensation
___________ and ____________ induce anginogenesis.
(a)
Highlight the main difference between both the apoptotic pathways
Intrinsic pathway: cytochrome C, Caspase 9
Extrinsic pathway: death receptors, Caspase 8
Which of these are anti-apoptotic?
I) Bax IV) Bcl-2
II) Bcl-xL V) PUMA
III) Bak
I and II
I and III
II and IV
III, IV and V
All the above
