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"Did I really study pharmacology during the ECQ? Hmmmmmmmmm"

Total questions: 35

Worksheet time: 18mins

Name
Class
Date
1.

This neurotransmitter controls the influx and efflux of Na & K.

a)

GABA

b)

Glutamate

c)

Enkephalin

d)

Dynorphin

e)

Substance P

2.

What device usually determines brain activity regarding seizures?

a)

EEG

b)

ECG

c)

MRI

d)

CT Scan

e)

Thermometer

3.

Which of the following types of seizure can lead to loss of consciousness?

a)

A. Partial Seizure

b)

B. Focal Seizure

c)

C. Generalized seizures

d)

A & B

e)

E. all

4.

This part of the brain, when stimulated, leads to the formation of spots or flashing lights.

a)

. Frontal lobe

b)

Parietal lobe

c)

Temporal lobe

d)

Occipital lobe

5.

This part of the brain, when stimulated can cause jacksonian seizure:

a)

Frontal lobe

b)

Parietal lobe

c)

Temporal lobe

d)

Occipital lobe

6.

Consisting of repetitive jerking of a particular muscle groups which spreads, involving much of the body within about 2 minutes before dying out:

a)

Simple partial seizure

b)

Complex partial seizure

c)

Partial seizure with 2ndary generalized seizure

d)

Generalized seizure

7.

This type of seizure alters the consciousness and causes behavioural changes:

a)

Simple partial seizure

b)

Complex partial seizure

c)

Partial seizure with 2ndary generalized seizure

d)

Generalized seizure

8.

A seizure that arises from both cerebral hemisphere:

a)

Simple partial seizure

b)

Complex partial seizure

c)

Partial seizure with 2ndary generalized seizure

d)

Generalized seizure

9.

This happens when Focal seizures become generalized and is accompanied by loss of consciousness:

a)

Simple partial seizure

b)

Complex partial seizure

c)

Partial seizure with 2ndary generalized seizure

d)

Generalized seizure

10.

Brief loss of consciousness, with minor muscle twitches and eye blinking:

a)

Tonic clonic seizure

b)

Absence seizure

c)

Myoclonic seizure

d)

Status epilepticus

e)

Febrile seizure

11.

This seizure leads to sudden loss of all muscle tone:

a)

Tonic clonic seizure

b)

Absence seizure

c)

Myoclonic seizure

d)

Atonic seizure

e)

Febrile seizure

12.

Is a condition in which patients experience recurrent episodes of tonic-clonic seizure without regaining consciousness:

a)

Tonic clonic seizure

b)

Absence seizure

c)

Myoclonic seizure

d)

Status epilepticus

e)

Febrile seizure

13.

Which of the following agents would not be an ALTERNATIVE to phenobarbital in the treatment of partial seizures?

a)

Primidone

b)

Carbamazepine

c)

Felbamate

d)

Lamotrigine

14.

Drugs that are especially useful in the treatment of petit mal epilepsy include:

a)

Phenobarbital

b)

Trimetadione

c)

Carbamazepine

d)

Ethosuximide

15.

This anticonvulsant drug has the broadest spectrum of activity:

a)

Valproic acid

b)

Felbamate

c)

Phenytoin

d)

Primidone

e)

Lamotrigine

16.

The pathophysiologic basis for antiparkinsonism therapy is:

a)

A selective loss of dopaminergic neurons

b)

The loss of some cholinergic neurons

c)

The loss of the GABAergic cells

d)

The loss of glutamatergic neurons

17.

Which of the following neurotransmitters is involved in Parkinson′s disease?

a)

Acetylcholine

b)

NE

c)

Substance P

d)

None

18.

Principal aim for treatment of Parkinsonian disorders is:

a)

To restore the normal balance of cholinergic and dopaminergic influences

b)

To reduce dopaminergic activity with levodopa and dopamine antagonists

c)

To increase glutamatergic activity with glutamate antagonists

d)

All of the above

19.

Indicate the drug that induces parkinsonian syndromes:

a)

Chlorpromazine

b)

Diazepam

c)

Levodopa

d)

Carbamazepine

20.

Which of the following drugs is used in the treatment of Parkinsonian disorders?

a)

Phenytoin

b)

Selegiline

c)

Haloperidol

d)

Fluoxetine

21.

Select the agent, which is preferred in the treatment of the drug-induced form of parkinsonism:

a)

Levodopa

b)

Bromocriptine

c)

Benztropine

d)

Dopamine

22.

Which of the following agents is the precursor of dopamine?

a)

Bromocriptine

b)

Levodopa

c)

Selegiline

d)

Amantadine

23.

The main reason for giving levodopa, the precursor of dopamine, instead of dopamine is:

a)

Dopamine does not cross the blood-brain barrier

b)

Dopamine may induce acute psychotic reactions

c)

Dopamine is intensively metabolized in humans

d)

All of the above

24.

Indicate a peripheral dopa decarboxylase inhibitor:

a)

Tolcapone

b)

Clozapine

c)

Carbidopa

d)

Selegiline

25.

Which of the following preparations combines carbidopa and levodopa in a fixed proportion?

a)

Selegiline

b)

Sinemet

c)

Tolcapone

d)

Biperiden

26.

Which of the following agents is the most helpful in counteracting the behavioral complications of levodopa?

a)

Tolcapone

b)

Clozapine

c)

Carbidopa

d)

Pergolide

27.

Which of the following vitamins reduces the beneficial effects of levodopa by enhancing its extracerebral metabolism?

a)

Pyridoxine

b)

Thiamine

c)

Tocopherol

d)

Riboflavin

28.

Which of the following drugs antagonizes the effects of levodopa because it leads to a junctional blockade of dopamine action?

a)

Reserpine

b)

Haloperidol

c)

Chlorpromazine

d)

All of the above

29.

Indicate D2 receptor agonist with antiparkinsonian activity:

a)

Sinemet

b)

Levodopa

c)

Bromocriptine

d)

Selegiline

30.

Which of the following antiparkinsonian drugs has also been used to treat hyperprolactinemia?

a)

Benztropine

b)

Bromocriptine

c)

Amantadine

d)

Levodopa

31.

Indicate a selective inhibitor of monoamine oxidase B:

a)

Levodopa

b)

Amantadine

c)

Tolcapone

d)

Selegiline

32.

The main reason for avoiding the combined administration of levodopa and an inhibitor of both forms of monoamine oxidase is:

a)

Respiratory depression

b)

Hypertensive emergency

c)

Acute psychotic reactions

d)

Cardiovascular collapse and CNS depression

33.

Indicate selective catechol-O-methyltransferase inhibitor, which prolongs the action of levodopa by diminishing its peripheral metabolism:

a)

Carbidopa

b)

Clozapine

c)

Tolcapone

d)

Rasagiline

34.

Which of the following antiparkinsonian drugs is an antiviral agent used in the prophylaxis of influenza A?

a)

Selegiline

b)

Sinemet

c)

Pergolide

d)

Amantadine

35.

Which of the following antiparkinsonism drugs is an anticholinergic agent?

a)

Amantadine

b)

Selegilin

c)

Trihexyphenidyl

d)

Bromocriptine