A 46-year-old patient went to the doctor complaining of pain in the small joints of the legs and arms. The joints are enlarged and have the appearance of thickened nodes. Serum contains elevated urate content. This can be caused by:

The patient's feces is normally stained but contains a large amount of free fatty acids. The reason for this is a violation of:

On examination of a man of 45 years, who was on a plant diet for a long time, a negative nitrogen balance was revealed. What feature of the diet has become the cause of the phenomenon?

In alkaptonuria there is an excessive excretion of homogentisic acid from the urine. Which amino acid disorder is associated with the onset of this disease?

The cause of pellagra disease may be predominant corn nutrition and reduced diet in animal products. Absence in the diet of which amino acid leads to this pathology?

The patient with chronic hepatitis showed a significant decrease in the synthesis and secretion of bile acids. What process will be most affected in this patient's intestine?

In clinically healthy parents, a baby was born, suffering from phenylketonuria. What are the genotypes of parents?

A few weeks after the birth, a baby began to show signs of CNS damage, skin and hair became light. When adding to fresh urine 5% solution of trichloroacetic iron, an olive-green color appears. What is the most likely diagnosis?

A 65-year-old man complained to the doctor about complaints of acute pain in the toes. He loves and often drinks beer. Gout was suspected. To confirm the diagnosis of which of the following substances should be determined in the blood?

It is known that phenylketonuria arises from the mutation of the gene responsible for the conversion of the phenylalanine amino acid and its decomposition to the end products of metabolism - CO₂ and H₂O. Indicate which phenylalanine metabolism pathway will lead to the development of phenylketonuria.

A 67-year-old man has cerebral atherosclerosis. The examination revealed hyperlipidemia. The content of which class of blood plasma lipoproteins is most likely to be significantly increased in biochemical studies?

An electrophoretic study of the serum of a patient with pneumonia showed an increase in one of the protein fractions. Specify it:

A child suffering from phenylketonuria suffers from mental retardation. What mechanism will be central to the development of damage to the central nervous system?

A 35-year-old man has a pheochromocytoma. The level of adrenaline and norepinephrine is increased in the blood, the concentration of free fatty acids increased by 11 times. Activation of which enzyme under the influence of adrenaline promotes lipolysis?

Which of the following substances stimulate the hunger center of the hypothalamus?

Which of the following endocrine pathologies may cause obesity?

Which of the following hormones activate lipolysis