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Herpesviruses

Total questions: 14

Worksheet time: 7mins

Name
Class
Date
1.

The following are the characteristic features of Herpesviridae family EXCEPT

a)

Replication in the host cell cytoplasm

b)

Establish latent infections

c)

Persists indefinitely and undergoes periodic reactivation

d)

Reactivated infection may be clinically different

2.

The glycoprotein that is type-specific for differentiation of HSV1 and HSV2 is

a)

Glycoprotein G

b)

Glycoprotein C

c)

Glycoprotein B

d)

Glycoprotein D

3.

The following are B herpes viruses EXCEPT

a)

CMV

b)

HHV6

c)

HHV7

d)

HHV8 or KSHV

4.

Recurrences of genital herpes are

a)

More with HSV-2 than HSV-1

b)

Same in both HSV-1 and HSV-2

c)

More in HSV-1 than HSV-2

d)

Variable and insignificant with either type of HSV

5.

Oral Acyclovir therapy in the treatment of chickenpox leads to the following EXCEPT

a)

Prevents the development of Zoster

b)

Shortens the duration of lesion formation

c)

Reduces the total number of new lesions by 25 %

d)

Diminishes constitutional symptoms in one-third of patients

6.

For the diagnosis of generalized herpes infection was studied blood serum to detect specific antibodies of specific class. Antibodies of which class indicate the acute phase of viral infection?

a)

Ig M

b)

Ig A

c)

Ig E

d)

Ig D

e)

Ig. G

7.

The main route of transmission of herpes simplex virus:

a)

Alimentary

b)

Contact

c)

Parenteral

d)

Air and dust

e)

Transplacental

8.

As a rapid diagnosis of herpes infection apply:

a)

Enzyme Immunoassay

b)

The reaction of neutralization

c)

Immunofluorescence method

d)

Radioimmunoassay

e)

The reaction of hemagglutination

9.

A patient has fever and the appearance of vesicles, which are located on the edge of the skin and mucous membranes. Through which research methods can confirm the presence in the patient of herpes simplex virus?

a)

Microscopic and allergic

b)

Virological and serological

c)

Virological and biological

d)

Serological and biological

e)

Microscopy and biological

10.

Patient appealed to the dentist complained of vesicular rash around the mouth. Which method should be applied to confirm the diagnosis "herpes"?

a)

Microscopic examination of smears

b)

Heamagglutinin

c)

Seeding on blood agar

d)

Seeding to Kitt Tarotstsi medium

e)

Immunofluorescence reaction

11.

To the hospital a woman at the age of 23 was admitted who during pregnancy has not passed routine microbiological and virological survey. Her baby has immediately after birth the skin and mucous small bubbles on the face of limited swollen spots. Later developed the damage of central nervous system and the baby was not saved. When sowing the contents of the bubbles in the blood agar growth of the pathogen have been identified, and during infection of tissue culture they observed CPE (simplasty, intranuclear inclusions, degeneration of cells). Which organism is the most likely causative agent of neonatal infections?

a)

Staphylococcus

b)

Gonococcus

c)

Chlamydia

d)

Herpes simplex virus

e)

Cytomegalovirus

12.

The family Herpesviridae subfamily Alphaherpesvirinae belongs to:

a)

Varicella-zoster virus

b)

The virus of smallpox

c)

Coxsackie virus

d)

Cytomegalovirus

e)

Epstein-Barr virus

13.

The family Herpesviridae subfamily Betaherpesvirinae belongs to:

a)

Herpes simplex virus

b)

Varicella zoster virus

c)

Cytomegalovirus

d)

Coxsackie virus

e)

Epstein-Barr virus

14.

The student of medical school, hospitalized in the infectious disease clinic, on the 2nd day of the disease is suspected infectious of mononucleosis. What is the result of laboratory tests can confirm the diagnosis of a student on the day of admission?

a)

Detection of Ig M-antibodies to herpes simplex virus

b)

Detection of Ig M-antibodies to the Epstein-Barr virus

c)

Identification of 4-fold rise of antibodies to Epstein-Barr virus

d)

Isolation (separation) of the herpes virus

e)

Detection of antibodies to cytomegalovirus