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WorksheetsHIV (general)
Total questions: 15
Worksheet time: 8mins
Lack of antibodies to the causative agent of AIDS:
always testifies about the absence of infection;
natural for the seronegative period of infection;
is observed at the terminal stage of AIDS.
Indicate family viruses that belongs to HIV:
Picornaviridae;
Paramixoviridae;
Herpesviridae;
Retroviridae;
Orthomixoviridae.
Choose positions
valid for the HIV genome:
(+) RNA;
(-) RNA;
DNA;
retro-RNA;
Biological substrates in which contained epidemically
a significant concentration of HIV, are:
saliva;
lacrimal fluid;
blood;
urine;
sperm;
Specify the main pathogenetically significant HIV target:
macrophages;
dendritic cells;
CD8 T lymphocytes;
CD4 T-lymphocytes;
B lymphocytes;
PROPERTIES FOR ACUTE phases of HIV infection:
clinical specificity;
mandatory seropositivity (anti-HIV antibodies);
a drop in the ratio between CD4and CD8 T lymphocytes
(CD4 / CD8 ratio);
high level HIV virusemia;
fast (weeks)
PROPERTIES for latent (chronic) phase HIV infection:
lack of clinical
Symptoms
seropositivity (anti-HIV antibodies);
high level HIV virusemia;
a progressive decrease in the number of CD4 T-lymphocytes;
self-sustainability;
Indicate serological markers that can be used in the diagnosis of HIV infection:
HIV antibodies;
HIV RNA;
HIV provirus;
HIV antigens;
CD4.
What methods and means are used to inactivate HIV in medical tools and other contaminated objects
boiling, solutions: 0.2 hypochloride, 0.5: formalin, 0.5 Lugol's solution, 70 degree alcohol, 6% H2O2
drying at room temperature
freezing
100% alcohol
Factors of Immune System Impairment in HIV Infection Leading to AIDS is
decreased production of natural antibodies
change in the number and functional activity of CD -4 lymphocytes
disruption of cytokine production
violation of the activity of subpolations of T - and B lymphocytes
What are the mechanisms of HIV entry into sensitive cells?
Virion RNA interacts with sensitive cells
gp 120 HIV interacts with CD4 antigens of lymphoid cells, gp 41
causes the fusion of the viral and cell membranes
HIV is captured by fragocytic cells that carry it throughout the body and transmit to virus-sensitive cells
DNA - provirus interacts with T-lymphocytes
What HIV envelope antigen interacts with target cell receptors
gp-120
gp-30
gp-41
gp-24
Name the membrane protein (receptor) of the cell membrane sensitive to HIV surface antigen
CD-8
CD-4
CD-3
CD-124
What fluctuations in the incubation period are most often observed in HIV -infections
1 to 16 weeks
3 to 12 weeks
1 to 2 weeks
1 to 3 days
Who are at-risk for HIV?
prostitutes, blood recipients, drug ussers
children born to HIV-infected mothers
pregnant
hepatitis patients
