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WorksheetsPathology: Lower Urinary Tract and Male Genital System
Total questions: 38
Worksheet time: 22mins
The top of the diaper is often noted to be damp on a girl infant. Radiologic imaging with contrast enhancement shows that there is a connection from bladder to umbilicus. What is the most likely diagnosis?
Congenital diverticulum
Exstrophy
Persistent urachus
Vesicoureteral reflux
A 43 year old businessman visits his primary care physician complaining of a purulent penile discharge. He had unprotected sex with a woman he met at a conference a week ago. Gram stain of the discharge fails to reveal any organism. Which of the following is the most likely cause of the discharge?
Bowen disease
Chlamydia trachomatis
Neisseria gonorrhoeae
Treponema pallidum
Points of ureteric narrowing where renal calculi may become impacted when they pass from the kidney to the bladder, except
Ureteropelvic junction
where they cross the pelvic brim over distal end of common iliac
Ureterovesicular junction
Where they cross the iliac vessels
No exception
True statements of Ureteropelvic junction obstruction, except
Congenital disorder that is the most common cause of hydropnephrosis in infants and children
More common in women in adults and often bilateral
More common in males during early life and is usually bilateral
May be due to excess stromal deposition of collagen between smooth muscle bundles
Intrinsic causes of ureteral obstruction, except
Tumor
Endometriosis
Blood clots
Calculi
Bladder cancer is more common in males and painless hematuria is a common presenting symptom
True
False
A 3 year old boy is brought to the pediatrician because his mother noticed an abnormal mass in his scrotum while changing his diapers. Further work up revealed elevated levels of serum alpha-fetoprotein. Which of the following is the most likely diagnosis?
Endodermal sinus (yolk sac) tumor
Choriocarcinoma
Hepatocellular carcinoma
Leydig cell (interstitial) tumor
Most common type of germ cell tumor
Teratoma
Seminoma
Endodermal sinus (yolk sac) tumor
Choriocarcinoma
A 23 year old african-american who is known to have sickle cell anemia presents to the emergency department with a painful erection. The patient claimed that the erection had started 3 hours prior. This condition is referred to as
Phimosis
Peyronie disease
Priapism
Balanitis
The most commonly used and effective medical therapy for symptoms relating to benign prostatic hyperplasia is
Alpha blocker
5-alpha reductase
Transurethral resection of the prostate
Any of the above
Adenocarcinoma of the prostate is the most common form of cancer in men
True
False
This is the most aggressive variant of prostate cancer
A. Colloid carcinoma of the prostate
B. Small cell cancer
C. Neuroendocrine carcinomq
B and C
PSA is organ and cancer specific
True
False
The most common treatment for clinically localized prostate cancer
Radical prostatectomy
Alpha blockers
5 alpha reductase
Transurethral resection of the prostate (TURP)
A 66 year old nan visits his family physician with complaints of urinary frequency, hesitancy, and dysuria. Digital rectal exam revealed an enlarged prostate with nodular and rubbery consistency. Serum PSA is increased. Which if the following is most closely related to the pathogenesis of the disorder described
DHT
hCG
Testosterone
Alpha fetoprotein
A 32 yr old man noticed an increased feeling of heaviness in his scrotum for the past 10 months. On PE, the left testis is 3x the size of the right testis and is firm on palpation. UTZ shows 6cm solid mass within the body of the left testis. There is elevated serum alpha fetoprotein. Which cellular components is most likely present in the mass
Yolk sac cells
Seminoma cells
Embryonal carcinoma cells
Cytotrophoblasts
All of the following causes hemorrhagic cystitis, except?
Adenovirus
cyclophosphamide
Cytotoxic antitumor drugs
No exception
A 45 year old patient with an end stage renal disease came in for routine check up. He complains of pain and tenderness in the lower abdomen. Upon PE, you noted that his indwelling catheter is still patent with free flowing urine. What is the most likely cause of his symptom?
Urinary retention
Interstitial cystitis
Chronic pelvic pain syndrome
Polypoid cystitis
Lesion of the urinary bladder in which brunn nests grow downward into the lamina propria where epithelial cells in the nests undergo metaplasia and take on a cuboidal or columnar appearance
Cystitis glandularis
Cystitis cystica
Cystitis cystica et glandularis
Intestinal or colonic mucosa
Distinct precursor lesions to invasive urothelial carcinoma, except
Non-invasive papillary tumors
Flat invasive urothelial tumor
Carcinoma in situ
Flat non invasive urothelial tumor
Most aggressive testicular carcinoma
Choriocarcinoma
Seminoma
Yolk sac tumor
Leydig cell tumor
A 23 year old previously healthy man suddenly developed severe pain in the scrotum. The pain continues unabated for 6 hours and was brought to the emergency room. On PE, he is afebrile. There is tenderness on the slightly enlarged tight testis. Gross appearance of right testis is shown. Which of the ff is the likely cause?
Lymphatic obstruction
Obstruction of blood flow
Hemorrhagic choriocarcinoma
Previous vasectomy
High grade muscle invasive urothelial tumors, except
A. Loss of function mutation TP53
B. loss of function mutation in RB tumor suppressor gene
C. Activating mutations in HRAS oncogene
A and B
Less than 10% of low grade urothelial cancers invade, but 80% of high grade urothelial cancers are invasive.
True
False
Dominant and sometimes only clinical manifestation of bladder cancer
Frequency
Urgency
Painless hematuria
Dysuria
Fibrous bands around the corpus cavernosum of the penis causing penile curvature and pain during intercourse.
Phimosis
Peyronie disease
Hypospadias
Epispadias
A 42 year old, sexually active, male came in due to a solitary, thickened, gray-white, opaque plaque involving shaft of his penis. As well as multiple shiny red, velvety plaques on his glans penis. What is the most likely diagnosis?
A. Bowen disease
Peyronie disease
C. Bowenoid papulosis
Both A and C
True of penile cancer, except
Found in patients between ages of 40 and 70 years
Circumcision confers protection
HPV type 18 is the most frequent culprit
Cigarette smoking increases risk of developement
An 18 year old man came in for routine health examination. On PE, you noted that there is no left testis palpable in the scrotum. The patient has no other illnesses and has normal sexual function. Which of the following complications will most likely occur?
A. Carcinoma
B. Infection
C. Infertility
A and C
Inflammation due to gonorrhea and tuberculosis is more common in
Testis
Epididymis
Both
Neither
Stage of testicular tumor when after orchiectomy, there is persistent elevation of HCG or AFP concentration even if lymph nodes are of normal size by imaging studies
Stage I
Stage II
Stage III
II and III
Most common form of testicular neoplasm in mean older than age 60.
Leydig cell tumor
Sertoli cell tumor
Gonadoblastoma
Testicular lymphoma
In the prostate, most hyperplasia arise in the transitional zone while most carcinomas arise in the peripheral zone
True
False
Most common for
of prostatitis
Acute bacterial prostatitis
Chronic bacterial prostatitis
Chronic abacterial prostatitis
Granulomatous prostatitis
Urinary obstruction is the major clinical problem seen in benign prostatic hyperplasia. This is due to?
Increased size of protate
Smooth muscle mediated prostatic contraction
Both
Neither
Products that may delay or prevent prostate cancer, except
Lycopenes
Tomatoes
Fats
Soy products
Vitamin D
A 70 year old, previously healthy man came in for routine PE. On palpation, there was a nodule in his normal sized prostate. Lab studies show a serum PSA level of 17ng/mL. A routine urinalysis showed no abnormalities. Which histologic findings is most likely to be found in a subsequent biopsy specimen of his prostate?
Acute prostatitis
Chronic abacterial prostatitis
Nodular hyperplasia
Adenocarcinoma
ProstatiC intraepithelial neoplasia
A 30 year old man has noticed bilateral breast enlargement over the past 6 months. On PE, breasts are enlarged without masses. Right testis is firm and larger than this left testis. Serum estrogen is High. UTZ shows a circumscribed 2cm mass in the body of the right testis. A right orchiectomy is performed. The mass is grossly uniform, with brown cut surface. Microscopic appearance is shown in the picture. Most likely diagnosis?
Choriocarcinoma
Leydig cell tumor
Gonadoblastoma
Embryonal carcinoma
Yolk sac tumoe
