WorksheetsIN SILICO METHODS
Total questions: 20
Worksheet time: 20mins
1. Which one is used for molecular docking?
a.
HEX
b. Maestro
c. KEGG
d. UniProt
2. __________ is the small molecule database
a. KEGG
b. Zinc
c. UniProt
d. NCBI
3. ADME stands for
a. Absorption, Distribution, Metabolism and Excretion
b. Administration, Distribution, Metabolism and Excretion
c. Absorption, disintegration, Metabolism and Efficacy
d. Administration, disintegration, Metabolism and Efficacy
4. _________ could be a drug molecule
a. Small molecule
b. Ion
c. Peptide
d. All the above
5. What kind of interaction typically involved in the binding of drug to the active site of the target protein
a. van der Waals interaction
b. ionic bond
c. H-bond
d. All the above
6. ________ the most common drug target?
a. DNA
b. RNA
c. G-protein coupled receptor
d. None of the above
7. HTVS
a. High Throughput Virtual search
b. High throughput Virtual screening
c. Hit-Identification Through Virtual Screening
d. Hit-identification Through Virtual search
8. __________ is the protein structure database
a. UniProt
b. SwissProt
c. Swiss Model
d. PDB
9. Lipinski’s Rule of Five includes
a. Molecular weight
b. HBD
c. HBA
d. All the above
10. Appraise the compound Doxorubicin for compliance with the Rule of Five parameter
Molecular weight = 543 g mol-1
LogP = -1.33
HBD = 7
HBA = 12
a. Number of violation 3
b. Number of violation 2
c. Number of violation 1
d. No violation
Which of the following is not include to computer-aided drug discovery for lead discovery....
a. Library design
b. Docking scoring
c. Target Flexibility
d. Target druggability
These followings are the part of SARS-Cov 2, except.
a. spike glycoprotein
b. protein membrane
c. envelope membrane protein
d. genomic DNA
Drugs candidate can be attached to protein target via mechanism below, except?
a. phi phi stacking
b. hidrophobic
c. metal binding
d. hidrogen binding
Which of the following is not an application of computational methods in drug discovery?
a. QSAR
b. Molecular Docking
c. Cell line testing
d. Virtual Screening
Which format will support to Autodock Vina
PDB
SDF
MOL
Which one of the following software used for protein file conversion
Pyrx
OpenBabel
Autodock
iGemdock
What is AutoDock used for?
A software tool for protein-ligand docking, predicting how small molecules bind to a receptor.
A database for storing protein sequences.
A simulation software for protein folding.
A tool for visualizing molecular structures.
What is Prokka used for?
A software tool for annotating genes in prokaryotic genomes.
A database for storing genomic sequences.
A tool for visualizing protein structures.
A platform for conducting phylogenetic analysis.
What does BLAST stand for?
Basic Local Alignment Search Tool
Biological Local Alignment Search Tool
Basic Local Alignment Sequence Tool
Biological Local Alignment Sequence Tool
TYpe name Roll nO and university name or college name
