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WorksheetsPharmacology - I
Total questions: 30
Worksheet time: 15mins
What does “pharmacokinetics” include?
Pharmacological effects of drugs
Unwanted effects of drugs
Chemical structure of a medicinal agent
Distribution of drugs in the organism
What is implied by active transport?
Transport of drugs trough a membrane by means of diffusion
Transport without energy consumption
Engulf of drug by a cell membrane with a new vesicle formation
Transport against concentration gradient
Which route of drug administration is most likely to lead to the first-pass effect?
Sublingual
Oral
Intravenous
Intramuscular
Pharmacodynamics involves the study of following EXCEPT:
Biological and therapeutic effects of drugs
Absorption and distribution of drugs
Mechanisms of drug action
Drug interactions
What does “affinity” mean?
A measure of how tightly a drug binds to plasma proteins
A measure of how tightly a drug binds to a receptor
A measure of inhibiting potency of a drug
A measure of bioavailability of a drug
If an agonist can produce maximal effects and has high efficacy it’s called:
Partial agonist
Antagonist
Agonist-antagonist
Full agonist
What phenomenon can occur in case of using a combination of drugs?
Tolerance
Tachyphylaxis
Accumulation
Synergism
A teratogenic action is:
Toxic action on the liver
Negative action on the fetus causing fetal malformation
Toxic action on blood system
Toxic action on kidneys
Therapeutic index (TI) is:
A ratio used to evaluate the safety and usefulness of a drug for indication
A ratio used to evaluate the effectiveness of a drug
A ratio used to evaluate the bioavailability of a drug
A ratio used to evaluate the elimination of a drug
The primary mechanism of action of local anesthetics is:
Activation of ligand-gated potassium channels
Blockade of voltage-gated sodium channels
Stimulation of voltage-gated N-type calcium channels
Blockade the GABA-gated chloride channels
Most serious toxic reaction to local anesthetics is:
Seizures
Cardiovascular collapse
Respiratory failure
All of the above
Acetylcholine is not a specific neurotransmitter at:
Sympathetic ganglia
Sympathetic postganglionic nerve endings
Parasympathetic ganglia
Parasympathetic postganglionic nerve endings
Indicate the location of M2 cholinoreceptor type:
Heart
Glands
Smooth muscle
Endothelium
Indicate a cholinomimetic agent, which is related to direct-acting drugs:
Edrophonium
Physostigmine
Carbachol
Isoflurophate
M3 receptor subtype is located:
In the myocardium
In sympathetic postganglionic neurons
On effector cell membranes of glandular and smooth muscle cells
On the motor end plates
Indicate the skeletal muscle relaxant, which is a depolarizing agent:
Vencuronium
Scopolamine
Succinylcholine
Hexamethonium
Indicate the agent, which effectively antagonizes the neuromuscular blockade caused by nondepolarizing drugs:
Atropine
Neostigmine
Acetylcholine
Pralidoxime
A bronchial smooth muscle contains:
Αlfa1 receptor
Αlfa2 receptor
Beta 1 receptor
Beta 2 receptor
Indicate the alfa1-selective antagonist:
Phentolamine
Dihydroergotamine
Prazosin
Labetalol
Which of the following agents is an alfa2–selective antagonist?
Yohimbine
Tamsulosin
Tolazoline
Prazosin
Hypnotic drugs are used to treat:
Psychosis
Sleep disorders
Narcolepsy
Parkinsonian disorders
Indicate the mechanism of barbiturate action (at hypnotic doses):
Increasing the duration of the GABA-gated Cl- channel openings
Directly activating the chloride channels
Increasing the frequency of Cl- channel opening events
All of the above
Which neurons are involved in parkinsonism?
Cholinergic neurons
GABAergic neurons
Dopaminergic neurons
All of the above
The mechanism of carbidopa′s action is:
Stimulating the synthesis, release, or reuptake of dopamine
Inhibition of dopa decarboxilase
Stimulating dopamine receptors
Selective inhibition of catecol-O-methyltransferase
Indicate a selective inhibitor of monoamine oxidase B:
Levodopa
Amantadine
Tolcapone
Selegiline
Neuroleptics are used to treat:
Neurosis
Psychosis
Narcolepsy
Parkinsonian disorders
Lithium carbonate is useful in the treatment of:
Petit mal seizures
Bipolar disorder
Neurosis
Trigeminal neuralgia
Which of the following agents is related to tricyclic antidepressants?
Nefazodon
Amitriptyline
Fluoxetine
Isocarboxazid
Which of the following antidepressants is a selective serotonin reuptake inhibitor?
Phenelzine
Desipramine
Maprotiline
Fluoxetine
Indicate the agents of choice in the treatment of most anxiety states:
Barbiturates
Benzodiazepines
Lithium salts
Phenothiazines
