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WorksheetsMECHANISMS OF DRUG ACTION
Total questions: 12
Worksheet time: 24mins
TRUE regarding effects of drug action:
An alteration in a function or process that maintains the existence of the living organism.
Drugs may increase the normal function of tissues or organs
Drugs may decrease the normal function of tissues or organs
Drugs may confer new functions of tissues or organs
(X) = The capacity of a drug to form the complex with its receptor (DR complex)
(a)
(X) = The ability of a drug to trigger the pharmacological response after forming the DR complex (receptor level)
(a)
(X) = Any molecule which selectively binds to particular receptors or sites
(a)
TRUE regarding types of bonds
Covalent bonds are irreversible
Electrostatic bonds require exchange of hydrogen ion
Van der Waals bonds are between charged atoms
The selectivity of drug receptor interaction is brought about by a single force/bond
Effect of drugs A + B = Effect of drug A + Effect of drug B
describes which type of combined drug effect?
(a)
Effect of drug A + B > Effect of drug A + Effect of drug B
describes which type of combined drug effect?
(a)
Effect of drug A + B < Effect of drug A + Effect of drug B
describes which type of combined drug effect?
(a)
CORRECT pairs include:
AGONIST - Fentanyl
PARTIAL AGONIST - Codiene
INVERSE AGONIST - Nalmefene
ANTAGONIST - Naloxone
Name X & Y
X = partial agonist, Y = inverse agonist
X = partial antagonist, Y = partial agonist
X = inverse agonist, Y = partial antagonist
X = inverse antagonist, Y= inverse agonist
TRUE regarding pharmacological antagonism
Reversible antagonism cannot be overcome by increasing concentration of agonist
Irreversible antagonism lasts for duration of receptor turnover
Non-competitive antagonism is surmountable
Omeprazole vs histamine is an example of reversible antagonism
Label X & Y
X = competitive antagonist
X = non-competitive antagonist
Y= competitive antagonist
Y = non-competitive antagonist
