WorksheetsAcromegaly
Total questions: 10
Worksheet time: 5mins
Which of these hormones is not secreted at the anterior pituitary gland?
Somatotropth cells
Lactotropes
Oxytocin
Gonadotropes
Which of the following is the most common cause of acromegaly?
Increase growth hormone releasing hormone (GHRH) from hypothalamic tumours
Ectopic GHRH from non endocrine tumours
Pituitary adenomas or hyperplasia
Ectopic GH secretion by non ecdocrine tumours
Which of the following is accurate about the epidemiology of acromegaly?
Gigantism is more common than acromegaly
Acromegaly is typically associated with a delay in diagnosis
The mean age for onset of acromegaly is the second decade of life
Men develop acromegaly more frequently than women
Which of the following symptoms is more common in individuals with acromegaly?
Visual field defect
Hyperprolactinemia
Sex steroid deficiency
Prognathism
Which statement is TRUE about skin manifestation in acromegaly?
Cutis verticis gyrate is a result of altered cutaneous circulation and dermal glycosaminoglycan accumulation
Skin puffiness are due to excess of GH and IGF-1 on skin cells and adnexae
Psoriasis is a manifestion
Cutis vercitis gyrate is a lesion over the extensor
These are causes of acromegaly except ?
Ectopic hypothalamic GHRH hypersecretion
GH hypersecretion from ectopic pituitary adenomas
Peripheral tumours like pancreatic islet tumour or lymphoma
TSH-oma
These are the genetic causes of acromegaly except ?
McCune Albright syndrome
Multiple endocrine neoplasia (MEN) type II
Carney complex
Familial isolated pituitary adenoma (FIPA)
Which of the following is accurate regarding the workup of acromegaly?
Routine imaging studies should be performed in all patients suspected of having acromegaly
GH is the most reliable biochemical indicator of acromegaly
Most patients investigated for acromegaly have a post glucose GH that is intermediate (5-10 ng/mL)
Elevated IGF-1 values in a patient suspected of acromegaly almost always indicate GH excess
Which of the following is accurate regarding treatment of acromegaly?
Pharmacologic therapy is the first line treatment for acromegaly
Radiation therapy is routinely indicated for most patients with acromegaly
For most patients with acromegaly, surgical removal of the pituitary gland tumour is the primary treatment
Somatostatin and dopamine analogues and GH receptor anatagonists should be routinely instituted if surgery for acromegaly is required
Which of these statement is NOT TRUE
Prolonged exposure to excess GH and IGF-1 does not increases overall mortality in patients with acromegaly
Elevated GH and IGF-1 are associated with increased cardiovascular mortality
Cardiomyopathy is common and can progress to systolic heart failure
Increased risk of colon cancer
