WorksheetsPT716A_Day3_18601917108_Pilot Plant Scale Upfor liquidorals
Total questions: 20
Worksheet time: 10mins
what are the steps followed for manufacturing Liquid Oral Dosage form?
Planning of material requirements
Liquid preparation
Filling and Packing
Quality assurance
simple solution are hard to scale up but they are required tanks of adequate size and suitable mixing capacity.
True
False
For manufacturing Liquid Oral dosage form, the equipment should possess good (a) to effect rapid dissolution of component of the system.
in formation of suspension the purpose of wetting agent is-
Protecting the API
Maintaining the suspension appearance
Facilitating the connection between API and vehicle
Masking the unpleasant taste/smell
the purpose of Buffering-systems and antioxidants is in manufacturing of suspension:-
Facilitating the connection between API and vehicle
Protecting the API
Maintaining the suspension appearance
Masking the unpleasant taste/smell
the purpose of the suspending and flocculating agent is
Masking the unpleasant taste/smell
Maintaining the suspension appearance
Facilitating the connection between API and vehicle
Protecting the API
the addition and dispersion of suspending agents on a laboratory scale may involve mixing the material using (a) .
During scale up of manufacturing suspension, rapid and complete hydration of suspending agents need to ensure.
false
true
(a) is used to prepare a concentrated slurry using small proportion of vehicle in preparation of suspension.
what are the critical factors required to hydrate suspending agent?
time
pH
temperature
Partition Co-efficient
to manufacturing an ideal suspension, active ingredients in suspension must be uniformly dispersed throughout the batch.
true
false
the best dispersion procedure of API in preparation of suspension mainly depends on_______________________characteristics of API.
biological
physical
chemical
both physical and chemical
having which of the following properties in the API, it can be added at any convenient stage in the manufacturing process?
it has good wettability
it does not agglomerate
it is difficult to wet
it tends to agglomerate
if the API is difficult to wet and tends to agglomerate,then which of the following steps are followed in preparation of suspension?
a wetting agent should be used to prepare a concentrated slurry
the API is dispersed in a small volume of liquid using high shear mixing equipment.
can be added at any convenient stage .
then it is dispersed in rest of the medium.
during manufacturing process of suspension, the equipment must be selected according to which factors?
size of the batch
the maximum viscosity of product
Emulsions are disperse system similar to suspension except that are dispersed phase is (a) instead of solid.
Processing parameters and procedures that must be adjusted and controlled emulsions include-
Temperature
mixing and homogenizing equipment
in process or final product filters
screen pumps and filtering equipment
the physical properties of emulsion are affected by - (a) .
which of the following statement is/are false?
manufacturing systems that utilizes high shear mixer are more likely to lead to air entrapment and may enhance the physical and chemical stability of API.
the use of vessels that can be operated within the contents under a controlled vacuum avoids the problems of unwanted aeration.
during manufacturing of emulsions,the unwanted particles are most efficiently removed by filtering the separate oil and water phases before emulsification.
true
false
