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Worksheetsmicrotoxicology #2
Total questions: 11
Worksheet time: 7mins
Toxicological chemistry deals with the following:
study the fate of the toxicants
deals with thermodynamics and energy release/absorb by the toxicants
deals with the uses and origin of the material
how to dispose the materials
What phase does the breaking of low and high molecular weight toxicants involves?
I
II
III
IV
What chemical reactions undergoes in a Phase I metabolism?
hydrolysis of esters
conjugation with sulphate
reduction of aldehyde
epoxidation of alkene
Which of the these statements is/are true about Phase II metabolism?
conjugation of sulphate by PAPS to become ionizable at physiological pH
conjugation happens to have a more lipophilic product
xenobiotic materials that underwent phase I conjugates with bioconjugating agents
conjugation with glucoronic acid by UDP-GA to become ionizable at physiological pH
A toxicant undegoes ADME
kinetic phase
dynamic phase
Phase I
Phase II
The toxicant interacts with the cells to make a toxic response
kinetic phase
dynamic phase
Phase I
Phase II
Which of the following effects happens in a dynamic phase?
inhibition of enzymes
inhibition of O2
disruption of lipid metabolism
cell membrane regeneration
Which of the following chemicals can cause depletion of oxygen transport?
HCN
CO
HCl
H2S
Which of the following chemicals can cause inhibition of electron transport chain?
HCN
CO
HCl
H2S
Which of the following chemicals can intercalate in the DNA
HCN
CO
HCl
Ethidium bromide
Carcinogenic agents are primarily
chemical agents
biological agents
ionizing agents
selective breeding agents
