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Pharmacokinetics / Pharmacodynamics

Total questions: 20

Worksheet time: 13mins

Name
Class
Date
1.

A pharmacology student asks the instructor what the accurate description of a drug agonist is. What is the instructor's best response?

a)

A drug that reacts with the receptor site on a cell preventing a reaction with another chemical on a different receptor site.

b)

A drug that interferes with the enzyme systems and act as catalyst for different chemical reactions.

c)

A drug that interacts directly with receptor sites to cause the same activity that a natural chemical would cause at the site.

d)

A drug reacts with receptor site to block normal stimulation, producing no effect.

2.

What factor influences drug absorption?

a)

Kidney function

b)

Route of administration

c)

Liver function

d)

Cardiovascular function

3.

The patient is taking low-dose aspirin daily for his heart. The nurse knows only a portion of the medication taken actually reaches the tissue due to what process?

a)

Distribution

b)

First-pass effect

c)

Reduced absorption

d)

Gastrointestinal circulation

4.

The patient who is diagnosed with cancer is receiving Morphine to relieve cancer pain. Approximately every 7 days, the medication is no longer effective in controlling the patient's pain and needs a larger dose to have the same effect. How will you explain to the patient what's happening?

a)

Tolerance

b)

Adverse Drug Reaction

c)

Adverse Drug Event

d)

Allergy

5.

A nurse is providing an oral medication for pain relief to a client. To attain the fastest pain relief,

the nurse administers the medication so that it is most rapidly absorbed from the gastrointestinal

(GI) tract. Which mode of delivery has the fastest absorption?

a)

Tablet

b)

Enteric-coated Tablet

c)

Gel capsule

d)

Liquid suspension

6.

A client asks why she needs to take a medication on an empty stomach. The nurse explains that

food generally has which effect on drug dissolution and absorption?

a)

Enhances

b)

Increases

c)

Decreases

d)

Does not have an effect

7.

A client asks why the oral dose of her pain medication is higher than the intravenous dose. The

nurse explains that with the oral dose, only 20% to 40% of the drug may actually enter systemic

circulation. This reduces the amount of active drug. What is the term for this effect?

a)

Hepatic first-pass effect

b)

Bioavailability

c)

Protein binding

d)

Drug absorption

8.

When providing a medication, which route should the nurse select to ensure the maximum

amount of bioavailability?

a)

Oral route

b)

Subcutaneous route

c)

Intravenous

d)

Intramuscular

9.

Isoproterenol (Isuprel) is an example of a medication that enhances the beta receptors in the

body. What is the term for drugs that stimulate a response?

a)

Antagonist

b)

Agonist

c)

Protein receptors

d)

Hormones or neurotransmitters

10.

These are physiologic effects not related to the desired effect, which can be predicted or associated with the

use of the drug, may also occur.

a)

Severe adverse reactions

b)

Side effects

c)

Synergistic effects

d)

Toxic effects

11.

Which of the following enteral administration routes have the largest first-pass effect?

a)

Sublingual

b)

Buccal

c)

Rectal

d)

Oral

12.

What organ is responsible for the metabolism in the "first pass effect"?

a)

Brain

b)

Heart

c)

Liver

d)

Lungs

13.

Drugs fit receptors using the lock and key model. Covalent bonds are the ___, while ionic and hydrogen bonds are ____.

a)

Strongest; weak

b)

Weakest; strong

c)

None is correct

14.

Pharmacokinetics is the effect of the ____; and Pharmacodynamics is the effect of the _____.

a)

Drug on a drug; Body on the drug

b)

Body on the drug; Drug on a drug

c)

Drug on the body; Body on the drug

d)

Body on the drug; Drug on the body

15.

Which ofthe following is NOT an action of the body on a drug?

a)

Absorption

b)

Distribution

c)

Metabolism

d)

Side Effects

16.

Which of the following can produce a therapeutic response? A drug that is:

a)

Bound to plasma albumins

b)

Concentrated in the bile and urine

c)

Not absorbed in the GI tract

d)

Unbound to plasma proteins

17.

Which of the following metabolically active tissues is the principal organ for drug metabolism?

a)

Skin

b)

Kidneys

c)

Liver

d)

GI Tract

18.

Which of the following drugs will not require a receptor-drug interaction to elicit a therapeutic response? Select all that applies.

a)

Epinephrine

b)

Anesthetic gases

c)

Antacids

d)

Paracetamol

19.

Given this situation, which has greater potency as an analgesic?


Paracetamol 500mg

Ibuprofen 200mg

a)

Paracetamol

b)

Ibuprofen

c)

Both

d)

None

20.

Given this situation, which has more efficacy as an analgesic?


Paracetamol 500mg

Ibuprofen 200mg

a)

Paracetamol

b)

Ibuprofen

c)

Both

d)

None