WorksheetsPharmacokinetics / Pharmacodynamics
Total questions: 20
Worksheet time: 13mins
A pharmacology student asks the instructor what the accurate description of a drug agonist is. What is the instructor's best response?
A drug that reacts with the receptor site on a cell preventing a reaction with another chemical on a different receptor site.
A drug that interferes with the enzyme systems and act as catalyst for different chemical reactions.
A drug that interacts directly with receptor sites to cause the same activity that a natural chemical would cause at the site.
A drug reacts with receptor site to block normal stimulation, producing no effect.
What factor influences drug absorption?
Kidney function
Route of administration
Liver function
Cardiovascular function
The patient is taking low-dose aspirin daily for his heart. The nurse knows only a portion of the medication taken actually reaches the tissue due to what process?
Distribution
First-pass effect
Reduced absorption
Gastrointestinal circulation
The patient who is diagnosed with cancer is receiving Morphine to relieve cancer pain. Approximately every 7 days, the medication is no longer effective in controlling the patient's pain and needs a larger dose to have the same effect. How will you explain to the patient what's happening?
Tolerance
Adverse Drug Reaction
Adverse Drug Event
Allergy
A nurse is providing an oral medication for pain relief to a client. To attain the fastest pain relief,
the nurse administers the medication so that it is most rapidly absorbed from the gastrointestinal
(GI) tract. Which mode of delivery has the fastest absorption?
Tablet
Enteric-coated Tablet
Gel capsule
Liquid suspension
A client asks why she needs to take a medication on an empty stomach. The nurse explains that
food generally has which effect on drug dissolution and absorption?
Enhances
Increases
Decreases
Does not have an effect
A client asks why the oral dose of her pain medication is higher than the intravenous dose. The
nurse explains that with the oral dose, only 20% to 40% of the drug may actually enter systemic
circulation. This reduces the amount of active drug. What is the term for this effect?
Hepatic first-pass effect
Bioavailability
Protein binding
Drug absorption
When providing a medication, which route should the nurse select to ensure the maximum
amount of bioavailability?
Oral route
Subcutaneous route
Intravenous
Intramuscular
Isoproterenol (Isuprel) is an example of a medication that enhances the beta receptors in the
body. What is the term for drugs that stimulate a response?
Antagonist
Agonist
Protein receptors
Hormones or neurotransmitters
These are physiologic effects not related to the desired effect, which can be predicted or associated with the
use of the drug, may also occur.
Severe adverse reactions
Side effects
Synergistic effects
Toxic effects
Which of the following enteral administration routes have the largest first-pass effect?
Sublingual
Buccal
Rectal
Oral
What organ is responsible for the metabolism in the "first pass effect"?
Brain
Heart
Liver
Lungs
Drugs fit receptors using the lock and key model. Covalent bonds are the ___, while ionic and hydrogen bonds are ____.
Strongest; weak
Weakest; strong
None is correct
Pharmacokinetics is the effect of the ____; and Pharmacodynamics is the effect of the _____.
Drug on a drug; Body on the drug
Body on the drug; Drug on a drug
Drug on the body; Body on the drug
Body on the drug; Drug on the body
Which ofthe following is NOT an action of the body on a drug?
Absorption
Distribution
Metabolism
Side Effects
Which of the following can produce a therapeutic response? A drug that is:
Bound to plasma albumins
Concentrated in the bile and urine
Not absorbed in the GI tract
Unbound to plasma proteins
Which of the following metabolically active tissues is the principal organ for drug metabolism?
Skin
Kidneys
Liver
GI Tract
Which of the following drugs will not require a receptor-drug interaction to elicit a therapeutic response? Select all that applies.
Epinephrine
Anesthetic gases
Antacids
Paracetamol
Given this situation, which has greater potency as an analgesic?
Paracetamol 500mg
Ibuprofen 200mg
Paracetamol
Ibuprofen
Both
None
Given this situation, which has more efficacy as an analgesic?
Paracetamol 500mg
Ibuprofen 200mg
Paracetamol
Ibuprofen
Both
None
