WorksheetsAntimycobacterial and antileprotic agents
Total questions: 20
Worksheet time: 12mins
TB caused by consumption of unpasteurized milk containing
M. avium
M. bovis
M. hominis
M.microti
Function of Mycolic acids
Resists against hydrophilic and lipophilic antibiotics
Loss of water
Both of the above
None of the above
Symptoms and signs of TB
A cough for 3 weeks
Fatigue
loss of apatite
Fever
Third line anti-tubercular agent
Clarithromycin
linezolid
Kanamycin
Rifabutin
If R1&R2- Alkyl gr & R3 -H in Isoniazide is showing less activity
True
False
Ethambutol which enantiomer is more active
Dextro
Meso
Levo
Threo
Refampicin is a semi-synthetic rifamycin made from Rifamycin
A
B
C
D
OH group required at which position for attachment to DDRP
C-1
C-8
C-21
C-23
All of the above
Role of Para amino salicylic acid
An alternative substrate
Competitive inhibitor
Block hepatic acetylation of isoniazid
MDR Tuberculosis
Masking of the OH group as ether or ester results into loss of activity.
True
False
Active metabolite of Ethionamide
Ethionamide sulfoxide
Ethylisonicotinamide
Ethylnicotinamide
Ethionamide sulfide
Cycloserine containing ----------------hetero-cyclic ring
Quinazoline
Thiazolidine
Pyrimidine
Isoxazolidine
Cycloserine inhibits
Alanine resemase
Alanine ligase
Alanine isomerase
Alanine nucleases
Peripheral nerve thickening in leprosy
True
False
Prodrug of Dapsone
Solapsone
Aminodapsone
Acedapsone
Methanedapsone
Resistance which develops during monotherapy in an individual patient with dapsone
Primary
Secondary
Persisters
None of the above
Priority of halogen substitution on para position of the 2 phenyls at C-3 and N-10
Br>Cl>F
Cl>Br>F
F>Cl>Br
F>Br>Cl
Ofloxacin can be used in alternative regimens in case rifampin cannot be used
True
False
In Paucibacillary leprosy
1-5 skin lesions
Treatment duration is 12 months
Skin smear positive at any site
No nerve/only one nerve involvement
Alternative regimen for Leporcy
Rifampin 600 mg + ofloxacin 400 mg + minocycline 100 mg
Rifampin 400 mg + ofloxacin 100 mg + minocycline 200 mg
Moxifloxacin 600 mg + minocycline 200 mg + rifampin 400 mg
Moxifloxacin 100 mg + minocycline 600 mg + rifampin 50 mg
