WorksheetsAlzheimer's disease
Total questions: 10
Worksheet time: 6mins
The two characteristic pathologies of Alzheimer's disease are...
Lewy bodies and neurofibrillary tangles
Amyloid plaques and neurofibrillary tangles
Ubiquitinated inclusions and amyloid plaques
Amyloid plaques and lewy bodies
What are the arrows pointing to in the image?
1 = amyloid plaque. 2 = neurofibrillary tangle
1 = amyloid plaque. 2 = lewy body
1 = mitochondria. 2 = nucleus
1 = neurofibrillary tangle. 2 = amyloid plaque
In the amyloidogenic pathway, which two enzymes cleave APP to produce the Aβ peptide?
γ-secretase and α-secretase
β-secretase and γ-secretase
β-secretase and α-secretase
Where about in the cell is the amyloid precursor protein (APP) found?
The nucleus
The cytoplasm
The plasma membrane
Mitochondria
Which protein is most commonly associated with neurofibrillary tangles?
Tau
Actin
APP
β-secretase
The function of tau is to [blank] microtubules
(a)
Neurofibrillary tangles are composed of...
Unphosphorylated tau
Microtubules
Hyperphosphorylated tau
Tubulin
Phosphorylated tau has a lower affinity for microtubules. True or false?
True
False
How many Braak stages are there in Alzheimer's disease?
Three, stages I-III
Six, stages I-VI
Ten, stages I-X
Seven, stages I-VII
The amyloid cascade hypothesis states:
Deposition of tau, the main component of the plaques, is the causative agent of Alzheimer’s pathology and that the neurofibrillary tangles, cell loss, vascular damage, and dementia follow as a direct result of this deposition
Deposition of Aβ, the main component of the plaques, is the causative agent of Alzheimer’s pathology and that the neurofibrillary tangles, cell loss, vascular damage, and dementia follow as a direct result of this deposition
Deposition of tau, the main component of the tangles, is the causative agent of Alzheimer’s pathology and that the plaques, cell loss, vascular damage, and dementia follow as a direct result of this deposition
Deposition of Aβ, the main component of the tangles, is the causative agent of Alzheimer’s pathology and that the plaques, cell loss, vascular damage, and dementia follow as a direct result of this deposition
