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WorksheetsRabies Virus
Total questions: 26
Worksheet time: 52mins
Family of rabies virus :
Retrovirodae
Lyssavirus
Enterovirus
Rhabdoviridae
Genus of rabies virus :
Retrovirodae
Lyssavirus
Enterovirus
Rhabdoviridae
General structure of rabies virus :
Enveloped, helical capsid, (-) ssRNA, non-segmented
Enveloped, helical capsid, (+)ssRNA, non-segmented
Non-enveloped, icosahedral capsid, dsDNA, non-segmented
Enveloped, helical capsid, ssDNA, segmented
Genome of rabies virus
contains 2 genes : Nucleoprotein (N), phosphoprotein (NS)
contains 3 genes : Nucleoprotein (N), phosphoprotein (NS), Matrix (M)
contains 4 genes : Nucleoprotein (N), phosphoprotein (NS), matrix (M), glycoprotein (G)
contains 5 genes : Nucleoprotein (N), phosphoprotein (NS), matrix (M), glycoprotein (G), polymerase (L)
Rabies can infect :
Lime-blooded animals
Arthropods
Amphibians
Crustaceans
Transmission of rabies virus :
Bite or scratch from a rabid animal or pet
Projection of infected saliva into conjunctiva, cornea transplant
Inhalation of infected aerosol
Eating the same plate and spoon
Talking to each other on phone
After being bitten by a rabies animal, rabid virus replicates primarily in
muscles
spinal cord
dorsal ganglia
brain
After the replication in muscles, rabies virus travels within axons in peripheral nerves to infect :
muscles
spinal cord
dorsal ganglia
brain
spinal cord, dorsal ganglia, then ascends to the brain
After infecting the brain, rabies virus has a centrifugal spread along nerves to
salivary glands
skin
eyes
All are correct.
Rabies virus incubates in racoon's body for approximately
7 days
1 week
3 - 12 weeks
10 - 20 weeks
Signs of disease of rabid animals :
Aggression
Abnormal behavior
Incoordination
Paralysis
All are correct.
The rabies-infected animal usually dies within
3 days of becoming sick
7 days of becoming sick
10 days of becoming sick
1 month of becoming sick
If your face were bitten by a rabies-infected animal, the incubation period of rabies virus would be
2 days
7 days
1 - 2 month
6 months or even years
If your distal body part were bitten or scratched by a rabies-infected animal, the incubation period of rabies virus would be
2 days
7 days
1 - 2 month
6 months or even years
Prodromal symptoms of rabies include :
Insomnia
Anxiety
Generalized hypersensitivity (Hydrophobia, aerophobia)
Pharyngolaryngeal hyperesthesia
All are included.
A complication of rabies virus :
Encephalitis
Fever
Renal failure
Blindness
Paralysis without hydrophobicity presents in
10% of rabies cases
20% of rabies cases
50% of rabies cases
80% of rabies cases
Samples for rabies virus :
Saliva
CSF
Skin biopsies
Brain (after death)
Corneal print
Direct diagnoses of rabies virus :
Direct immunofluorescence (IF) and immunoprecipitation (IP)
Virus isolation and culture
PCR test for viral RNA
ELISA for antigen detection
Seroneutralization (Anti-gpG IgG antibody)
Indirect diagnoses of rabies virus :
Direct immunofluorescence (IF) and immunoprecipitation (IP)
Virus isolation and culture
PCR test for viral RNA
ELISA for antigen detection
Seroneutralization (Anti-gpG IgG antibody)
The best cell for rabies virus culture is :
Murine neuroblastoma
Human embryonic fibroblast
Human embryonic lung cell
Renal cells
Preventive vaccination of rabies virus includes :
2 injections : D0 and D28 in one-month period every 3 years
3 injections : D0, D7 and D21 or D28 in one-month period for every 5 years
5 injections : D0, D3, D7, D14, D28
4 injections : D0 (2 injections), D7 and D21
Anti-rabies vaccination (for treatment) includes :
2 injections : D0 and D28 in one-month period every 3 years
3 injections : D0, D7 and D21 or D28 in one-month period for every 5 years
5 injections : D0, D3, D7, D14, D28
4 injections : D0 (2 injections), D7 and D21
Types of anti-rabies vaccine :
killed or inactivated
live-attenuated
intramuscular
intradermal
What should we do with the wounds after being bitten by a rabid animal?
Suture is required and urgent!
Washing, rinsing, disinfecting and applying antibiotics, antitetanic vaccine
Ignoring the wounds because they will not cause anything troublesome.
Eating more nutritional diet so that the viruses will be eliminated automatically without any treatment.
The most proper muscle to inject an intramuscular anti-rabies vaccine is :
deltoid
vetrogluteal
dorsogluteal
vastus lateralis
