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Respiration & GIT drugs

Total questions: 50

Worksheet time: 27mins

Name
Class
Date
1.

Which of the following drugs used for cough is contraindicated in patients with peptic ulcer?

a)

Noscapine

b)

Potassium iodide

c)

Carbocisteine

d)

Ambroxol

2.

Peripherally acting antitussive:

a)

Noscapine

b)

Prenoxdiazine

c)

Dextromethorphan

d)

Codeine

3.

Mode of action of Bromhexine:

a)

Mucopolysacharide digestion

b)

Mucoprotein opening

c)

Central action on cough centre

d)

Increase bronchial secretion

4.

Which of the following drugs are not used in acute asthma?

a)

Salmeterol

b)

Ipratropium

c)

Zafirlukast

d)

Budesonide

5.

Route of administration of adrenaline in patients with acute bronchial asthma

a)

Intramuscular

b)

Subcutaneous

c)

Intravenous

d)

Intradermal

6.

Oral drug useful in treatment of acute bronchial asthma

a)

Formoterol

b)

Bambuterol

c)

Ipratropium

d)

Adrenaline

7.

Water soluble but highly irritant methylxanthine:

a)

Theophylline

b)

Etophylline

c)

Aminophylline

d)

Doxophylline

8.

Methylxanthines cause all except:

a)

Diuresis

b)

Convulsions

c)

Gastritis

d)

Hypertension

9.

Theophylline toxicity can be seen with:

a)

Phenobarbitone

b)

Ciprofloxacin

c)

Rifampicin

d)

All of these

10.

Most preferred methylxanthine in premature infant apnoea:

a)

Theophylline

b)

Caffeine

c)

Aminophylline

d)

Doxophylline

11.

Preferred bronchodilators in COPD:

a)

Salbutamol

b)

Theophylline

c)

Tiotropium

d)

Formoterol

12.

Choose the false statement regarding Zafirlukast:

a)

Useful for mild chronic asthma prophylaxis

b)

Eosinophilia is seen as an ADR

c)

Poorly plasma protein bound

d)

Well tolerated

13.

Zileuton is seldom used due to:

a)

Nephrotoxicity

b)

Hepatotoxicity

c)

Peptic ulcer aggrevation

d)

Neurotoxicity

14.

Ketotifen has an additional:

a)

H2 blocking effect

b)

H1 blocking effect

c)

5-HT2 blocking effect

d)

LT antagonising effect

15.

Lipocortin inhibits

a)

Lipooxygenase

b)

Phospholipase

c)

Cyclooxygenase

d)

Corticosteroids

16.

Steroid given as a prodrug:

a)

Methylprednisolone

b)

Fluticasone

c)

Ciclesonide

d)

Budesonide

17.

Omalizumab prevents the binding of:

a)

Mast cell to histamine

b)

IgE to antigen

c)

IgE to mast cell

d)

Mast cell to antigen

18.

All of the following are contraindicated in asthma except:

a)

Ibuprofen

b)

Paracetamol

c)

Propranolol

d)

Bethanechol

19.

Ipecac should not be given for all except:

a)

Kerosene poisoning

b)

Amitryptiline poisoning

c)

Sulphuric acid poisoning

d)

Mercury poisoning

20.

Antiemetic preferred in Meniere's disease:

a)

Scopolamine

b)

Promethazine

c)

Ondansetron

d)

Domperidone

21.

Longest acting 5-HT3 antagonist:

a)

Granisetron

b)

Dolasetron

c)

Palonosetron

d)

Ramosetron

22.

Ramosetron is useful in:

a)

Motion sickness

b)

Irritable bowel syndrome

c)

Peptic ulcer

d)

Constipation

23.

Metoclopramide shows:

a)

5-HT4 agonism

b)

5-HT2 antagonism

c)

D2 agonism

d)

5-HT3 antagonism

24.

Metoclopramide is used in all except:

a)

GERD

b)

Gastroparesis

c)

Intractable hiccups

d)

Chalasia

25.

Preferred antiemetic in children:

a)

Ondansetron

b)

Metoclopramide

c)

Domperidone

d)

Dronabinol

26.

Domperidone and metoclopramide shows contrasting characteristics in all except:

a)

Action of atropine

b)

Extrapyramidal symptoms

c)

Prolactin levels

d)

Potency

27.

Drug causing Torsades de pointes:

a)

Mosapride

b)

Domperidone

c)

Cisapride

d)

Metoclopramide

28.

Cinitapride blocks:

a)

5-HT2

b)

5-HT3

c)

D1

d)

D2

29.

Choose the correct statement

a)

Scopolamine is an anticholinesterase used to prevent motion sickness

b)

Meclizine has a short duration of action

c)

Neuroleptics are useful in vomiting due to uremia

d)

Aprepitant increases the action of substance P

30.

Dronabinol is obtained from

a)

Marijuana plant

b)

Opium poppy

c)

Coca plant

d)

Papaver plant

31.

Active form of PPI

a)

Sulphonylurea

b)

Sulphonamide

c)

Sulfanilamide

d)

Sulphenamide

32.

Drug more potent than omeprazole:

a)

Lansoprazole

b)

Pantoprazole

c)

Ilaprazole

d)

All of these

33.

Choose the incorrect match

a)

Bleeding ulcers: i.v PPI

b)

H. pylori ulcers: antibiotics

c)

NSAID ulcers: Misoprostol

d)

Curling ulcers: Telenzepine

34.

All are adverse effects of PPIs except:

a)

Gynaecomastia

b)

Hypergastrinemia

c)

Osteoporosis

d)

Constipation

35.

All of the following drugs decrease the bioavailability of ketoconazole except:

a)

Sucralfate

b)

Mg(OH)2

c)

Misoprostol

d)

Sodium bicarbonate

36.

Which of the following drugs increase NO production?

a)

Nizatidine

b)

Famotidine

c)

Lafutidine

d)

Cimetidine

37.

Cimetidine & ranitidine differ in all except:

a)

Antiandrogenic effect

b)

Enzyme inhibition

c)

CNS side effects

d)

Competitive blockage

38.

Misoprostol is contraindicated in:

a)

Asthma

b)

Elderly

c)

Pregnancy

d)

Peptic ulcer

39.

Which of the following drugs should not be given with PPIs?

a)

Misoprostol

b)

Amoxycillin

c)

Sucralfate

d)

CBS

40.

A peptic ulcer patient reports blackening of tongue after treatment. The drug she might have been taking is:

a)

CBS

b)

Sucralfate

c)

Omeprazole

d)

Magnesium hydroxide

41.

Choose the correct statements:

a)

Magnesium salts cause constipation

b)

Aluminium salts cause diarrhoea

c)

Aluminium salts cause constipation

d)

Magnesium salts cause diarrhoea

42.

Drug causing rebound acidity

a)

Sodium bicarbonate

b)

Magnesium hydroxide

c)

Aluminium hydroxide

d)

Calcium carbonate

43.

Sodium alginate:

a)

Decreases frothing

b)

Causes frothing

c)

Local anesthetic

d)

Antibiotic property

44.

Simethicone is added to antacids to relieve :

a)

Constipation

b)

Diarrhoea

c)

Gastritic pain

d)

Flatulence

45.

Peptic ulcer regimen useful for a person with penicillin allergy:

a)

Triple regimen

b)

Quadruple regimen

c)

Both can be given

d)

None of these

46.

Standard daily dose of pantoprazole:

a)

10 mg

b)

20 mg

c)

30 mg

d)

40 mg

47.

Treatment of choice for Zollinger-Ellison syndrome:

a)

PPI

b)

H2 blocker

c)

Surgery

d)

Antacids

48.

A CCF patient should never take:

a)

Non systemic antacids

b)

PPIs

c)

Systemic antacids

d)

H2 blockers

49.

Nebulisation given for status asthmaticus includes:

a)

Salbutamol + hydrocortisone

b)

Salbutamol + terbutaline

c)

Salbutamol + ipratropium

d)

Salbutamol + budesonide

50.

Guaiphenesin:

a)

Mucolytic

b)

Demulscent

c)

Antitussive

d)

Expectorant