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WorksheetsANTI ARRHYTHMIA DRUGS
Total questions: 10
Worksheet time: 10mins
Which of the following drugs are sodium channel blockers? (multiple right answers)
Disopyramide
Qunidine
Dofetilide
Adenosine
Mexiletine
The following statement is true regarding Class I antiarrhythmic drugs:
Inhibits Phase 4 depolarization in SA and AV nodes
Prolongs Phase 3 repolarization in ventricular muscle fibers
Slows Phase 0 depolarization in ventricular muscle fibers
Inhibits action petential in SA and AV nodes
Use dependent drugs : (multiple right answers)
bind more rapidly to open or inactivated sodium channels than to channels at rest
show a greater degree of blockade in tissues that are frequently depolarizing
also known as state-dependent drugs
markedly affect normal low frequency heart rates
Propanolol reduces the incidence of sudden cardiac death after myocardial infarction partly because of its ability to prevent (X). What are (X)?
(a)
Class II agents: (multiple right answers)
diminish Phase 0 depolarization
depress automaticity
prolong AV conduction
decreases heart rate
decreases contractility
Class III antiarrhythmic drugs:
block Ca+ channels
diminish inward potassium current during depolarization
prolong duration of action potential
decrease the slope of Phase 0 depolarization
True regarding Class III anti-arrhythmic drugs: (multiple right answers)
Amiodarone is structurally related to thyroxine.
Dronedarone has a better safety profile than amiodarone.
Sotalol lengthens the effective refractory period
Class III drugs do not induce arrhythmias
True regarding Class IV anti-arrhythmic drugs
Block both activated and resting potassium channels.
Decrease the rate of Phase 4 spontaneous depolarization.
No effect on conduction in the AV node.
Safe for use in patients with depressed cardiac function.
The following statements are true regarding verapamil and diltiazem: (multiple correct answers)
Slows Phase 4 spontaneous depolarization
More effective in ventricular arrhythmias compared to atrial arrhythmias.
Have negative inotropic properties.
Is eliminated unchanged via the kidney.
Intravenous (X) is the drug of choice for treatment of acute supraventricular tachycardia. What is (X)?
(a)
