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WorksheetsPsychotropics
Total questions: 27
Worksheet time: 14mins
What property about fluoxetine makes it quite activating compared to other SSRIs?
5HT2C antagonism
Dopamine transporter inhibition
sigma 1 binding
5HT1A binding
Which of the following SSRIs has the most potent interaction at sigma 1 receptor sites, thus allowing for more optimal anxiolysis? (Also helps most with psychotic depression)
Sertraline
Paroxetine
Fluoxetine
Fluvoxamine
Which of the following combos is known as "California rocket fuel"?
Sertraline + Wellbutrin
Fluoxetine + Olanzapine
Duloxetine + Amytriptiline
Venlafaxine + Mirtazapine
Alcohol has what effect on GABA and glutamate in the VTA?
Increases GABA and decreases glutamate
Increases both GABA and glutamate
Decreases GABA and increases glutamate
Decreases both GABA and glutamate
Which of the following is a key agonist binding site for hallucinogens?
Cannabinoid 1 receptors
5HT2C receptors
5HT2A receptors
GABA-A receptors
Which of the following is true regarding the affinity of a majority of the atypical antipsychotics?
Higher affinity for D2 receptors than 5HT2A receptors
Higher affinity for 5HT2A receptors than D2 receptors
Comparable affinity for both D2 & 5HT2A receptors
wtf brah
How do you switch from a done to a pine?
Taper down the done for a week while up-titrating the pine over 2 weeks
Taper down the done for 2 weeks while up-titrating the pine for 1 week
maintain the dose of the done while up-titrating the pine, and then start to taper down the done
Taper down the done for a week while up-titrating the pine over 1 week
What are the benefits of brexipiprazole over aripiprazole?
Brexipiprazole = higher antipsychotic properties
Brexipiprazole = Less EPS
Brexipiprazole = more favorable metabolic profile
Brexipiprazole = less sedating
What does alpha 2 antagonism do to seratonin & norepinephrine?
Increase NE and no effect on 5HT
Increase 5HT and no effect on NE
Increase both
No effect on both
Which of the following is the most potent property of trazodone?
5HT2C antagonism
5HT1A antagonism
5HT2A antagonism
Serotonin Reuptake Inhibition
One must wait at least ___ half-lives after discontinuing a serotonergic drug before starting a MAO inhibitor
3
4
5
6
7
Which of the following TCA's should absolutely never be used with MAO inhibitors?
Clomipramine
Amitryptyline
Nortriptyline
Doxepin
Imipramine
Which class of antidepressants works better in women in the presence of estrogen? (i.e. more effective in pre-menopausal women than post-menopausal)
SSRIs
SNRIs
Vilazodone combines serotonin re-uptake inhibition with which second property?
NE re-uptake inhibition
5HT2C antagonism
Dopamine re-uptake inhibition
5HT1A partial agonism
Which antipsychotic must be given sublingually due to poor bioavailability if swallowed?
What is the blackbox warning of Risperidone?
Increased suicidal thoughts in ages 12-29
Increased chance of death in patients with dementia
Increased risk of pancreatitis
Increased risk of liver failure
Olanzapine helps improve mood in treatment resistant depression especially when combined with which of the following?
Venlafaxine
Sertraline
Escitalopram
Fluoxetine
What is the lowest effective dose of Quetiapine as an antipsychotic? (occupying 60% of D2 receptors)
200 mg
300 mg
400 mg
600 mg
At what daily dose of seroquel have clinical trials repeatedly shown to demonstrate robust antidepressant effects?
200 mg
300 mg
400 mg
600 mg
How do you switch from a done/pine to aripiprazole?
Taper down the pip/done while starting abilify at low dose and titrating up slowly over 1-2 weeks
Taper down the pip/done while starting abilify at a middle dose and quickly titrating up over a week
Taper down the pip/done while starting abilify at the preferred maintenance dose, no titration necessary
How do you switch from aripiprazole to a done/pine?
Stop abilify right away, and start the pine/done at middle dose and up-titrate
Taper down the abilify quickly over 1 week, while starting the pine/done at a middle dose and up-titrate
Taper down abilify slowly between 1-2 weeks, while starting the pine/done at a low dose and up-titrate
Stop the abilify right away, and start the pine/done at a low dose and up-titrate
Which of the following SNRIs has more potent NE reuptake inhibition compared to seratonin reuptake inhibition? (Thus making it more useful for chronic pain conditions)
Duloxetine
Milnacipran
Venlafaxine
Desvenlafaxine
Which of the following is the only FDA approved medication to treat pseudobulbar affect (The Joker)?
Amlodipine
Dextromethorphan
Sertraline
Nortriptyline
Which of the following is true regarding the dosing of duloxetine for depression?
Efficacy is dose-dependent, with greater response typically seen above 60 mg/day
There is no evidence of increased efficacy above 60 mg daily, though, some patients may benefit from it
The maximum dose is 60 mg per day due to significant increase in side effects at higher dose
idk
Which of the following is theoretically false regarding apathy?
It can be a residual symptom of depression
It can be a side effect of serotonergic antidepressants
It is hypothetically due to elevated dopamine
It is hypothetically due to elevated serotonin decreasing dopamine
Which of the following is a reasonable approach to treating an aging patient with schizophrenia who then develops Alzheimer's dementia?
Risks of cardiovascular events and death associated the Alzheimer's generally mean that antipsychotics should not be given even though the patient has long standing schizophrenia
Generally the need for treating schizophrenia and the benefits of antipsychotic treatment of this condition outweigh the risks associated with antipsychotics when given in the presence of the additional condition of Alzheimer's disease
Cholinesterase inhibitors alone reduce risk of mortality
Behavioral modification alone has shown to beneficial to reduce all causes mortality compared with antipsychotic treatment
If you want to add lamotrigine for a patient with a history of mood disorder who is currently on valproate, which of the following is the proper titration schedule?
Valproate does not affect the plasma levels of lamotrigine, and therefore, no adjustments to titration schedule is needed
Valproate increases the plasma level of lamotrigine, and thus the titration schedule should be halved
Valproate decreases the plasma levels of lamotrigine and thus the titration schedule should be doubled
Decrease dosage of Valproate during titration of lamotrigine
