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WorksheetsPolyclonal Antibodies
Total questions: 10
Worksheet time: 6mins
What is the difference between primary and secondary response in regards to antibody levels?
Secondary: higher, faster, shorter
Primary: Faster, lower, shorter
Secondary: Faster, higher, longer
Primary: Slower, lower, longer
Is a hapten immunogenic?
Yes
No
A carrier allows a hapten to:
increase in size
attach to multiple attachment sites
be immunogenic
to travel to spleen
An adjuvant has the following functions:
Increase the size of an antigen
Speed up release
Increase immunogenicity
Attract immune cells
FCA has one extra component compared to FIA. Which one?
Surfactant
Non-metabolisable oil
dead mycobacteria
Which adjuvant is approved for human usage?
FIA
MF-59 (oil/water)
Alum
Why would you choose a chicken as a animal to generate pAbs?
Has a lot of blood to give.
Young females have high immune response.
Can be breed pathogen free.
Antibodies can be harvested from egg yolk.
Which licenses are required from the Home office before starting animal work?
License for lab
License for animal facility
License for researcher
License for project
Immunisation schedule for a rabbit:
Why do you frequently bleed the animal?
To clean the blood
To weaken the animal
To remove the suppressive effect of high amount of antibodies
To stimulate the immune response
What is the most likely injection route for 200 ul vaccine in mouse?
intravenous
intraperitoneal
intramuscular
subcutaneous
