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WorksheetsCNS YEAR 2
Total questions: 22
Worksheet time: 14mins
Clinical features of stroke depends on
Site of lesion
Type of stroke
Age
Size of lesion
Most common site of embolic infarct
Anterior cerebral artery
Posterior cerebral artery
Middle cerebral artery
Superior cerebral artery
Benzodiazepam has antagonism drug interaction with
Diazepam overdose
Flumazenil
Cisplatin
Bromocriptine
Which of these are short acting benzodiazepines?
Lorazepam
Midazolam
Triazolam
Diazepam
Tetanus is
Granulomatous disease of peripheral nerves in mucosa
Prolonged contraction of skeletal muscle
Causing poor muscle tone and flaccid paralysis of muscle due to agents' toxin
Tetanospasmin are
Cause spasm
A hemolysin
Cause destruction of tissue
A neurotoxin
Lab diagnosis for cryptococcal meningitis
India ink preparation
Mantoux test
Culture on sabouraud's dextrose agar
Latex agglutination test
Which of these are true statements for trypanosoma cruzi
Amastigotes multiply by binary fission
Trypomastigotes multiply by binary fision
Have 3 stages, trypomastigotes, amastigotes, epimastigotes
Have 2 stages, trypomastigotes and epimastigotes
True statements for polio
Infected nerve cells lyses upon release of mature virus
Can cause paralytic polimyelitis
Prevention by Salk vaccine or Sabin vaccine oral polio vaccine
MOT is by bite of infected animals
True statements for rabies
Viral encephalitis
Infantile paralysis
Virus replication occurs in muscle
Not fatal
Most common viral encephalitis
Arboviruses
Hsv 1
EBV
Varcella zoster
CNS entry for sporadic viral encephalitis (HSV)
Direct neuronal spread
Haematogenous
Alzheimer disease affect area of
Basal ganglia & connections
Cerebellum & connections
Frontal & temporal lobe
Hippocampus & related cortical areas
Tau protein deposition in alzheimer disease are
In form of neurofibrillary tangles
In form of neuritic plaques
Outside neurons
Intracellular deposition
Gross features of alzheimer diseases
Cerebral atrophy in frontal and parietal lobe
Narrowing of gyri
Pallor of substantia niagra
Atrophy of caudate nucleus and putamen
MOA of phenytoin
Inhibit generation of action potential by binding to voltage dependent sodium channel
Increase GABA content of brain by inhibits GABA transaminase
Inhibit release of excitatory amino acid by blocking sodium and calcium influx into neuronal axon
Suppress T-type Ca current or blocks neuronal T-type Calcium channel
Which of these inhalational GA agents have pungemt smell, flammable and irritating
Halothene
Enflurane
Nitrous oxide
Ether
Why levodopa is given with carbidopa?
To prolong plasma half life of levodopa
To help levodopa cross BBB
To convert levodopa to dopamine
MAO B inhibitors are used to extend duration of action of L-DOPA by decrease metabolic degradation of dopamine in synaptic cleft
True
False
Which parkinson disease drug when administered, need routine monitoring of liver function test?
Amantadine
Tolcapone
Carbidopa
Biperiden
Adverse effect of tricyclic antidepressant
Coma
Conjunctivitis
Convulsion
Cardiotoxicity
MOA fir buspirone
Partial agonist with 5-HT 1A subclass of brain serotonin receptors
Activates melatonin receptors in suprachiasmatic nuclei of CNS
