Worksheets3.2.2 Karyotyping
Total questions: 10
Worksheet time: 6mins
What is a normal human karyotype? [tick all that apply]
22 pairs of autosomes
1 pair of sex chromosomes (XX or XY)
23 pairs of autosomes
1 pair of sex chromosomes (ZZ or WZ)
What is shown in a karyogram? [tick all that apply]
Chromosomes in pairs
Autosomes organised largest -> smallest
Sex chromosomes at the end
Maternal chromosomes on the left
What would be shown in the karyogram of a normal human female?
XX
XY
YY
X
What can be deduced from this karyogram? [tick all that apply]
Male
Female
Normal
Trisomy
Which chromosomal disorder is caused by trisomy 21?
Down syndrome
Edward syndrome
Turner syndrome
Which factor is associated with an increased risk of trisomy?
Increasing maternal age at birth
Increasing paternal age at conception
Maternal alcohol abuse during pregnancy
Paternal cigarette smoking
At what maternal age does the risk of trisomy increase exponentially?
25
30
35
40
Which method enables a fetal karyotype to be determined earliest?
CVS
Amniocentesis
Which method is associated with the lowest risk of miscarriage?
CVS
Amniocentesis
Why might a 36yo woman choose not to have a CVS procedure?
The risk of miscarriage is higher than the risk of trisomy
The risk of trisomy is higher than the risk of miscarriage
She wants to terminate the pregnancy if the fetus has trisomy
An amniocentesis can be done earlier
