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ceutics 2 exam 1

Total questions: 177

Worksheet time: 15hrs 45mins

Name
Class
Date
1.

How much Alcohol USP is required to preserve 200 mL of syrup containing 160 g of sucrose?

a)

2.25 ml

b)

1.15 ml

c)

1.12 ml

d)

2.75 ml

2.

Which of the following liquid dosage forms is considered a two phase system?

a)

Elixir

b)

Solution

c)

Emulsion

d)

Tincture

3.

Which of the physical chemical properties of a powder will enhance the drug dissolution? (Select all that will apply)

a)

Large particle size

b)

Small particle size

c)

Large specific surface

d)

Small specific surface

e)

Low equilibrium solubility

4.

A simple syrup only contains sucrose and purified water.

a)

True

b)

False

5.

Diluted Alcohol NF is prepared by mixing equal volumes of Alcohol USP and Purified Water USP. Therefore, the alcohol concentration of Diluted Alcohol NF is exactly half that of Alcohol USP

a)

True

b)

False

6.

In the preparation of elixirs, the first step is dissolving alcohol soluble ingredients in the alcohol and dissolving water soluble ingredients in the water. Then, the alcohol solution should be added to the aqueous portion.

a)

True

b)

False

7.

Indicate if the following statement is true or false. Plastic fluids or Bingham bodies do not begin to flow until a shearing stress corresponding to a yield value, f, is exceeded.

a)

True

b)

False

8.

Indicate if the following statement is true or false. Particle size of fine dispersion is larger than that of a colloidal dispersion.

a)

True

b)

False

9.

Indicate if the following statement is true or false. Increasing the contact angle will result in improving the wetting property of the particles in liquid medium.

a)

True

b)

False

10.

Indicate if the following statement is true or false. In general, interfacial tensions between two liquids is greater than interfacial tension between a solid and a liquid.

a)

True

b)

False

11.

TTDS- Drug in adhesive more comfortable and more dumping in adhesive

a)

True

b)

False

12.

TTDS- the area should be clean

a)

True

b)

False

13.

Which of the following will influence what goes inside the tablet density, particle size?

a)

True

b)

False

14.

Increase in tidal volume results in less penetration of aerosol particles deeper into the distal tracheobronchial and alveolar regions.

a)

True

b)

False

15.

Which one(s) is (are) the main advantages of the Drop-Tainer?

I. Decreased contamination potential

II. Higher weight

III. Lower cost

a)

I,II,III

b)

II only

c)

I only

d)

III only

16.

Deposition by diffusion decrease with the increase in particle size.

a)

True

b)

False

17.

Increase in tidal column results in _________ penetration of aerosol particles deeper into the _________ tracheobronchial and alveolar regions.

a)

less;proximal

b)

greater;proximal

c)

less;distal

d)

greater;distal

18.

For pressurized metered dose inhalers (PMDIs), the momentum of aerosol particles generated depends on the device rather than the patient’s IFR.

a)

True

b)

False

19.

Device must be kept vertical to ground to keep powder aerosolized (in the test they change to Vertical so is

a)

True

b)

False

20.

Reciprocal of viscosity: ___________

a)

Fluidity

b)

less fluidity

c)

Dense

d)

Thick

21.

Unit for rate constant is one of the striking differences between a zero and first order process?

a)

True

b)

False

22.

Which of the following (s) will influence drug release matrix type modified release dosage forms?

a)

Porosity (e) of the matrix

b)

Tortuosity (t) of the matrix

c)

Equilibrium solubility of a drug

d)

Compressional force applied to proper tablet

e)

All of the above

23.

When handling of gelatin capsules, during manufacturing as well as storage, the capsule should have a humidity range of?

a)

30-45 %

b)

20-30 %

c)

15-25 %

d)

20-45 %

24.

Which of the following represents the moisture content of the commercially available empty hard gelatin capsule?

a)

1-5 %

b)

6-10 %

c)

12-15 %

d)

20-25 %

25.

Angle of repose determines

a)

Lubrication

b)

Humidity

c)

dry

d)

Temperature

26.

Measurement of the wetting

a)

Contact Angle

b)

non-stick

c)

Bulk density

d)

particle size

27.

K type what determines what we put inside capsule.

a)

True density

b)

Bulk density

c)

Particle size

d)

dissolution

28.

What test is required by USP for tablets and capsules =

a)

content uniformity

b)

dissolution

c)

weight variation

d)

All of the above

29.

veterinary capsules are available

a)

10

b)

11

c)

12

d)

15

30.

Capsules are made with:

a)

Colorants

b)

Opaqueing agents

c)

Preservatives

d)

All of the above

31.

Which of the following will manifest directly proportional relationship when plotted only on a R.L. Paper?

a)

Absorbance against concentration

b)

True density against the weight of the powder

c)

True volume against the weight of the powder

32.

Which of the following dosage form (s) requires an incorporation of a lubricant as an adjuvant?

a)

immediate release tablet

b)

Hard gelatin capsule

c)

Soft gelatin capsule

33.

Which of the following excipients (s) is/are required to prepare an immediate release tablet dosage form?

a)

Diluent

b)

Binding agent

c)

Suspending agent

34.

Which of the following property (s) is/are common to all states of the matter?

a)

Kinetic energy

b)

Boiling point-liquid to gas

c)

Surface tension-liquid to liquid

35.

Which of the following is an appropriate unit for the parameter used to assess the extent of absorption?

a)

mcg*lit-1

b)

mcg*hr-1

c)

mcg*ml-1*h

d)

mcg*ml-1*h-1

36.

Which of the following properties is/are used to evaluate the flow of the powder material?

a)

Hausner’s Ratio-allow to measure the compressibility of powder ingredient (active and inactive ingredient together)

b)

Contact angle-will tell my about the hydrophobicity of the drug. Greater the contact angle the higher hydrophobicity.

c)

Angle of repose-measures the friction of the forces present in the powder material (ONY IN THE POWDER, no liquid). Ex powder to the funnel and pass normal the angle of repose is small

d)

Carr’s index-allow to measure the compressibility of powder ingredient (active and inactive ingredient together)

37.

Which of the following dosage form (s) is/are used for an oral as well as topical administration of a drug?

a)

Powder

b)

Tincture

c)

Lotion

d)

Elixir

38.

Which of the following can be obtained by employing the Clausius-Clapeyron Equation?

a)

Heat of solution

b)

Heat of vaporization

c)

Boiling point of a liquid

d)

Heat of fusion

39.

Which of the following profile (s) will exhibit directly proportional relationship?

a)

Absorbance against concentration (S. L. paper)

b)

Solubility against absolute temperature (S. L. paper)

c)

(AUC)0 against Dose (R.L.paper)

40.

Drugs are often formulated and administered orally as a capsule dosage form. Soft gelatin capsules are used to incorporate liquid formulations while hard gelatin capsules are used to incorporate powder formulations.

a)

True

b)

False

41.

Which of the following is/are considered as fundamental pharmacokinetics parameter (s) of a drug? – systemic clearance, elimination ½ life, elimination rate constant (1/hr) and volume of distribution.

a)

Creatinine clearance

b)

Systemic clearance

c)

Peak plasma concentration

42.

True density is one of the properties of a therapeutic agent that is important in pharmaceutics. The higher the true density, the greater is the amount of powder present per cubit centimeter space

a)

True

b)

False

43.

1. When it is necessary and required to obtain the value of an intercept form the graph of a straight-line equation, one may use two different available approaches. Each approach, however, requires knowledge of the slope of the graph. Slope or intercepts

a)

True

b)

False

44.

Which of the following property is considered as physical-Chemical property?

a)

Solubility

b)

Chemical Structure

c)

Systemic Clearance

45.

Which of the following best represents the unit for the onset of action, duration of action and termination of action?

a)

mg/hr

b)

Hours

c)

mcg/ml

46.

Which of the following sieve size will yield the powder particles with the smallest specific surface

a)

Size 20

b)

Size 40

c)

Size 60

d)

Size 10

47.

Which of the following excipients may serve as an effective adsorbing agent to prevent the eutectification of two powders?

a)

Kaolin

b)

Sodium Lauryl Sulfate

c)

Lactose

d)

Magnesium Stearate

48.

Which of the following hard gelatin capsule size will hold the smallest amount of a powder of a particular particle size and density?

a)

Size 3

b)

Size 4

c)

Size 2

d)

Size 0

49.

Which of the following is used as a suspending agent in the preparation of calamine lotion?

a)

Bentonite Magma

b)

Calcium Hydroxide solution

c)

Glycerin

d)

MIneral oil

50.

Which of the following is/are the active ingredient (s) in the calamine lotion?

a)

Ferric Oxide

b)

Magnesium oxide

c)

Calcium oxide

d)

Zin oxide

51.

Which of the following is used as a levigating agent in the preparation of calamine lotion?

a)

Glycerin

b)

MIneral oil

c)

Propylene glycol

d)

Cetyl alcohol

52.

Which of the following is a complete water-soluble ointment base?

a)

White ointment

b)

Rose water ointment

c)

Hydrophilic ointment

d)

PEG ointment

53.

While preparing an ointment base, when applicable, it is prudent to liquefy the ingredients of the base in the descending order of melting point

a)

True

b)

False

54.

Which of the following ingredients is a part of an aqueous phase while preparing an o/w type emulsion base?

a)

Stearyl alcohol

b)

Propylene Glycol

c)

White petrolatum

55.

Which of the following drug products is/are commercially available in a soft gelatin capsule dosage form?

a)

nifedipine

b)

depakene

c)

prometrium

56.

Which of the following test must be performed on hard gelatin capsule dosage form, soft gelatin capsule dosage form, and an immediate release tablet dosage form?

a)

Content uniformity

b)

Weight variation

c)

Dissolution

57.

1. Which of the following factor(s), according to an equation most frequently employed to describe the drug dissolution, will influence the dissolution of a therapeutic agent?

a)

Equilibrium solubility (Cs)

b)

Specific surface (A)

c)

Porosity

58.

Which of the following is true while describing the first order drug dissolution from a conventional tablet?

a)

Unit for the rate constant is mg/hr.

b)

A (R.L) plot of the cumulative amount of drug dissolved against time will be a straight line with positive slope

c)

Unit for the rate is mg/hr

59.

Which of the following is/are effective binding agent(s) for the preparation of an immediate release tablet containing a therapeutic agent that is susceptible to hydrolysis?

a)

Starch paste

b)

Acacia mucilage

c)

PVP aqueous solution

60.

The mean weight of twenty tablets of a commercially available Tylenol tablet (Lot#SJ040918) was found to be 475 mg. According to USP, therefore, eighteen out of twenty tablets should individually weigh between the following ranges.

a)

427.50 to 522.50 mg

b)

439.375 to 510.125 mg

c)

460.75 to 489.25 mg

d)

451.25 to 498.75 mg

61.

Which of the following will contribute to greater variation in the drug content uniformity results of an immediate release tablet dosage form?

a)

Poor flow of granules

b)

High porosity

c)

Inadequate binding agent

d)

Inadequate diluent

62.

1.

Which of the following is/are employed as a vehicle to prepare liquid formulation of a therapeutic agent to be filled into a soft gelatin capsule?

a)

Peanut oil

b)

Propylene glycol

c)

Oleic acid

63.

You are required to prepare 60 grams of an ointment base that contains 12% w/w of propylene glycol (sp. gravity 1.04 g/cc). How many milliliters of propylene glycol will be required to prepare this base?

a)

7.20

b)

7.48

c)

6.92 (7.2g/1.04g/cc)

d)

7.50

64.

Which of the following ingredient is a part of an aqueous phase while preparing an o/w type emulsion base?

a)

Stearic alcohol

b)

Propylene glycol

c)

White petrolatum

65.

Which of the following is used as a levigating agent in the preparation of calamine lotion?

a)

MIneral oil

b)

Glycerin

c)

Bentonite magma

d)

Calcium hydroxide solution

66.

Which of the following methods should be employed while incorporating a very small amount of an active ingredient in to an ointment base?

a)

Fusion method

b)

Congealing method

c)

Adsorption method

d)

Geometric dilution method

67.

Rose water ointments is an example of w/o emulsion

a)

True

b)

False

68.

Preservatives are added to o/w type ointment base

a)

True

b)

False

69.

o/w type ointment base is easy to wash with water

a)

True

b)

False

70.

agent which act as emulsified by________________.

a)

Forming a protective layer around the droplets of the internal phase

b)

Imparting a charge to the dispersed phase

c)

Swelling to increase the viscosity of the system

d)

Forming a monomolecular film around the droplets of the internal phase

71.

Surfactants are a class of emulsifying agent which act as emulsifiers by exhibiting an auxiliary effect of increasing the viscosity of the emulsion in addition to being adsorbed at the interface and reducing the interfacial tension. Is the above statement true or false?

a)

True

b)

False

72.

The absence of association between drug particles which occurs when repulsion forces between particles predominate will lead to the formation of a ________ suspension.

a)

deflocculated

b)

flucculated

c)

structured

d)

Stable

73.

Suspended particles become flocculated in a suspension, because

a)

Particles are closely packed

b)

Attractive forces between particles located at a distance are appreciable

c)

Repulsive forces between particles located at a distance are appreciable

d)

Suspension medium reject the

74.

A pseudo fluid displays a decrease in viscosity at a constant shear stress depending on whether the shear stress is increase or decrease?

a)

True

b)

False

75.

Flocculated suspensions are characterized

a)

Relatively lower sedimentation volume

b)

Relatively higher rate of sedimentation

c)

Absence of primary maximum

76.

Which of the following will reduce the rate of sedimentation of a suspension?

a)

Large particle size

b)

low viscosity

c)

high viscosity

d)

high true density of the powder

77.

Finely divided solids like Magnesium trisilicate, Aluminum hydroxide ect, are a class of emulsifying agents which act as emulsifiers by _____________

a)

imparting a charge to the dispersed phase

b)

Swelling to increase the viscosity of the system

c)

forming a protective layer around the droplets of the internal phase

d)

Forming a monomolecular film around the droplets of the internal phase.

78.

Which of the following values for contact angle with water corresponds to the most hydrophobic drug particle that would be least wetted by water?

a)

90o

b)

10o

c)

180o

79.

Higher compression = harder tablet, but not higher porosity.

a)

True

b)

False

80.

What makes divided powders difficult to formulate,

a)

hygroscopicity

b)

delinquence

c)

porosity

d)

surface area

81.

Wetting agent and water soluble lubricant:

a)

Glycerin

b)

Mineral oil

c)

Sodium lauryl sulfate

d)

magnesium sulfate

82.

Tartaric acid is used effervescent in

a)

granules

b)

chewable

c)

desintegration

d)

disperse

83.

Appropiate method for Low dose drugs

a)

wet granulation

b)

granulation

c)

hard gelatin

d)

soft gelatin

84.

Larger capsule size = higher capacity.

a)

False

b)

True

85.

What doesn’t improve solubility of a hydrophobic

substance

a)

grinding of powder to smaller particle size

b)

grinding of powder to larger particle size

c)

grinding of powder to smaller surface area

d)

grinding of powder to larger surface area

86.

Powder property suitable for hard gelatin capsules

a)

low compressibility

b)

high compressibility

c)

medium compressibility

d)

does not compressibility

87.

Using higher concentration of stearates retards dissolution, meaning long peak time and low peak conc.

a)

True

b)

False

88.

Most commonly used lubricant

a)

magnesium stearate

b)

mangesium sulfate

c)

glycerin

89.

larger sieve number means bigger particle size and higher specific surface.

a)

True

b)

False

90.

Enteric coated for insensitive drugs in acidic environment but dissolves in intestinal

a)

alkalinic

b)

neutral

c)

acidic

91.

Which test is a required USP for tablet ?

a)

Dissolution test.

b)

Disintegration test

c)

Stability test

92.

Harness test = stronger force = the harder tablet is and more porosity in the tablet

a)

False

b)

True

93.

Effervescence ingredient contains :

a)

tartaric acid.

b)

acetic acid

c)

ascorbic acid

d)

hydroxy acid

94.

Why Nitroglycerin is stored in glass container

a)

adsorption with plastic.

b)

adsoption with plastic fluid

c)

disintegrating with plastic.

95.

The higher Stearate concentration = retard dissolution = reduce rate of bioavailability = longer peak time and lower peak concent.

a)

True

b)

False

96.

Disintegration mechanism

a)

swell up

b)

give swell

c)

swell up a lot

97.

1. What influence the capsule size

a)

True density, bulk density and particle size not saturation solubility.

b)

True density, bulk density and particle size saturation solubility.

c)

True density, bulk density and surface area not saturation solubility.

d)

True density, bulk volume and particle size not saturation solubility.

98.

Deposition by diffusion _________ with the increase in particle size.

a)

decrease

b)

increase

99.

Ultrasonic nebulizers are quieter than air-jet nebulizers.

a)

True

b)

False

100.

The slower the peripheral blood flow of the eye, the poorer absorption of drug into the conjunctiva and sclera

a)

True

b)

False

101.

Opthalmic preparations should be terminally sterilized in the final packaging.

a)

False

b)

True

102.

Both unit-dose eye solutions and ophthalmic products for eye surgery need preservatives

a)

False

b)

True

103.

Which salt form is more recommended in the ophthalmic solutions ?

a)

nitrate

b)

salicylate

c)

bitartrate

d)

hydrobromide

104.

Rx:

§ Atropine Sulfate 2%

§ NaCl qs

§ Aqua dist. q.s. ad. 30 mL

§ M.ft.opthalmic solution

o E of atropine sulfate = 0.13

o E of boric acid = 0.50

o Boric acid is used the osmotic agent


Amount of Boric Acid to add is

a)

0.192 g

b)

0.384 g

c)

0.078 g

d)

0.27 g

105.

The eye drop bottle made by LDPE resin is usually sterilized by autoclave

a)

False

b)

True

106.

Valve discharge rate of an aerosol is the amount of the drug discharged per unit volume

a)

True

b)

False

107.

Mannitol is a commonly used tonicity adjusting ingredient in ophthalmic prarations

a)

True

b)

False

108.

Viscosity-imparting agents also serve as the lubricants in eye drops

a)

True

b)

False

109.

Rx:

§ Atropine Sulfate 2%

§ NaCl qs

§ Aqua dist. q.s. ad. 30 mL

§ M.ft.opthalmic solution

o E of atropine sulfate = 0.13

o NaCl is used the osmotic agent

o Amount of NaCl to add is

a)

0.192 g

b)

0.384 g

c)

0.078 g

d)

0.27 g

110.

Glycerine in ophthalmic solution is used for

a)

stabilizer

b)

co-solvent

c)

preservative

d)

lubricant

111.

Alcohol USP

a)

95 % v/v

b)

70 % v/v

c)

95 % w/v

d)

70% w/v

112.

Which of the following information must be submitted to the Food and Drug Administration (FDA) by an ethical as well as a generic pharmaceutical company in order to get an approval for a drug product?

a)

Expiradion date

b)

Results of phase I studies

c)

Result of pathological studies

d)

Results of toxicological studies

113.

Which of the following equation is commonly employed to describe the drug dissolution?

a)

Noyes-Whitney

b)

Fick' law

114.

Dissolution is usually an

a)

endothermic process

b)

exothermic process

115.

Solutions in pharmacy is mostly involved with:

a)

Solids dissolved in Liquids, Liquids mixed in Liquids

b)

Liquids dissolved in Liquids, Solids mixed in Liquids

116.

suppositories available for

a)

rectal

b)

urethral

c)

vaginal

d)

endo-vaginal

117.

Dosage forms or drug delivery systems can be broadly divided into:

a)

Solids dosage forms and Liquids dosage forms

b)

Aerosol or metered dosage inhaler (MDI)

c)

Semi-solids dosage forms and Transdermal drug delivery system

d)

Modified release dosage form or controlled release dosage forms

118.

Pharmaceuticals solvents and co-solvents internal

a)

Alcohol , USP

b)

MIneral oil

c)

Purified Water

d)

Ethanol

119.

Solvents & Co-solvents : External

a)

Glycerin

b)

Propylene glycol

c)

Isopropyl alcohol

d)

acetone

120.

The alcohol limitation of a OTC medication for children is 5%

a)

True

b)

False

121.

Diluted alcohol NF is mixing equal volumes of Alcohol, USP and Purified Water, USP.

a)

True

b)

False

122.

The strength of Diluted Alcohol, NF is approximately

a)

49%

b)

70%

c)

95%

d)

5%

123.

Diluted alcohol is a useful hydroalcoholic solvent in various pharmaceutical processes and preparations.

a)

True

b)

False

124.

Glycerin USP is

a)

A clear syrupy liquid with a sweet taste.

b)

Miscible with both water and alcohol.

c)

Used as emollient, co-solvent, preservative and stabilizer.

d)

Used as emollient and co-solvent

125.

The alcohol concentration of rubbing alcohol is

a)

70%

b)

95%

c)

49%

d)

10%

126.

Propylene glycol, a viscous liquid, is miscible with water and alcohol. Frequently used as glycerin substitute in modern pharmaceutical formulations.

a)

True

b)

False

127.

Purified water USP

a)

When evaporated to dryness, it must not yield greater than 0.001% of residue

b)

No for parenteral use

c)

is less free of solid impurities compared with drinking water.

128.

A simple syrup contains only sucrose and purified water

a)

True

b)

False

129.

Free water is preserved by 18% alcohol.

a)

Syrup USP

b)

Alcohol USP

c)

Water

d)

Elixir

130.

Alcoholic concentration of spirits is usually over 60%.

a)

True

b)

False

131.

Spirits are ____________ or _______________ solutions of volatile substances.

a)

Hydroalcoholic

b)

alcoholic

c)

aromatic

132.

Their alcohol content ranges from tinctures

a)

15-80% (30-160 proof)

b)

20-85 % (25-150 proof)

c)

30-160% (15-80 proof)

133.

Which of the following is true about the weak acidic drugs?

a)

They are available as sodium salt

b)

They are better absorbed of low pH

c)

They are better absorbed of high pH

d)

They are available as potassium salt

134.

Which of the following parameters are dimensionless?

a)

Partition coefficient

b)

Tortuosity

c)

Surface area

d)

Porosity

135.

Which of the following will influence the lipophilicity of a drug?

a)

Substituent groups

b)

Bulk density

c)

Particle size

d)

Apparent volume of distribution

136.

Which of the following belong to a class of a weak acidic drugs?

a)

Losartan Potassium

b)

Ibuprofen

c)

Metoprolol Succinate

d)

Codeine Phosphate

137.

Which of the following liquid dosage form represent a two-phase system?

a)

Elixir

b)

Ophthalmic solution

c)

Emulsion

d)

Solution

138.

Which of the following permits a assesment of hydrophobicity of a therapeutic angle?

a)

Contact angle

b)

Angle of repose

c)

Surface tension

d)

Partition coefficient

139.

Which of the following will be observed as a consequences of reduction of the particle size powder?

a)

Greater surface area

b)

Lower true density

c)

Higher true density

d)

Lower specific surface

140.

Which of the following dosage forms are used to administer a therapeutic agent orally as well as topicaly?

a)

Powder

b)

Tincture

c)

Cream

d)

Elixir

141.

Which of the following dosage forms requires presence of excipients?

a)

Oral tablet

b)

Oral solution

c)

Oral capsule

d)

Rectal suppository

142.

Which of the following physical-chemical property of a therapeutics agent plays an important role in a oral tablet dosage form?

a)

Particle size

b)

Particle shape

c)

Adsorption

d)

Viscosity

143.

Which of the following is/are considered as an advantage of a powder dosage form?

a)

Good chemical stabilitty

b)

Flexibility in compounding

c)

Ease of dispensing hygroscopic powder

d)

Ease of dispensing unpleasant tasting powder

144.

Which of the following type of therapeutic agents are ideally suited for the preparation of bulk powder as a dosage form?

a)

Antifungal

b)

Laxatives

c)

Anti-depressants

d)

Anti-hypertensive agents

145.

Which of the following represents a good example of bulk powder as a dosage form?

a)

Metamucil

b)

Aspirin

c)

Calcium carbonate

d)

Acetaminophen

146.

Which of the following is a desirable physical-chemical property of a therapeutics agent for the formulation of a topical powder?

a)

High specific surface

b)

High true density

c)

Low specific surface

d)

High true density

147.

Which of the following is/are effective excipients to minimize eutectification of a selected therapeutuc agent?

a)

Kaolin

b)

Talc

c)

Starch Powder

d)

Gelatin Powder

148.

Which of the following inactive ingredient is/are required to prepare effervescent granules for oral administration

a)

Sodium bicarbonate

b)

Sodium phosphate

c)

Sodium Chloride

d)

Sodium carbonate

149.

Which of the following sieve size yield the powder of largest specific surface?

a)

Sieve #200

b)

Sieve #20

c)

Sieve #120

d)

Sieve # 40

150.

Which of the following property of a drug is considered ideal for its development into a modified release dosage form?

a)

High dose

b)

Short elimination half-life

c)

High aqueous solubility

d)

Long elimination half-life

151.

Which of the following fluids are characterized by a non-linear decrease in viscosity with increase in shear rate?

a)

Newtonian fluids

b)

Plastic fluids

c)

Pseudo-plastic fluids

d)

Dilatant fluids

152.

Zeta potential controls the degree of attraction between adjacent, similarly charged dispersed particles.

a)

True

b)

False

153.

In general, the diameter of the initial phase for fine dispersions is greater than the diameter of the internal phase for colloidal dispersions.

a)

True

b)

False

154.

The solubitity of a week base increases when the pH increases. Assume the pH is higher than the pH max.

a)

True

b)

False

155.

The tablet has less irritation to the GI tract compared to the solution when a large dose is given.

a)

False

b)

True

156.

The drug formulated in the solution usually tends to degrade compare to that formulated in the suspension.

a)

True

b)

False

157.

The strenght of diluted alcohol , NFS is exactly half that of alcohol, USP.

a)

True

b)

False

158.

Glycerin can be used as preservative, stabilizer, and co-solvent.

a)

True

b)

False

159.

Rubbin alcohol can be used internaly

a)

False

b)

True

160.

Propylene glycol can be used as preservative, stabilizer and co-solvent.

a)

True

b)

False

161.

Cation free water has higher pH compared to the inlet water in the ion exchange method.

a)

False

b)

True

162.

The flow in this cross flow system is from a more concentrated to a less concentrated solution

a)

True

b)

False

163.

A simple syrup contains sucrose, purified water, and flavored substances.

a)

False

b)

True

164.

Syrups prepared by the heat have better stability compared to those prepared by the agitation.

a)

False

b)

True

165.

The alcohol content range of the elixirs is from 5-40 % and 10-80 proof

a)

True

b)

False

166.

The concentration of syrup USP is

a)

65% w/w

b)

85% w/v

c)

65% w/v

d)

85% w/w

167.

When you prepare elixirs by mixing two liquids, it is usually to add the aqueous phase to the alcohol solution.

a)

True

b)

False

168.

Tinctures are preparations by simply mixing the ingredients with the solvent

a)

True

b)

False

169.

Aromatic water usually has therapeutic function

a)

False

b)

True

170.

When the aromatic water is prepared by talc , talc is mixed with water first

a)

True

b)

False

171.

Which of the following represents the moisture content of the commercially available empty hard gelatin capsules ?

a)

12-15%

b)

6-10%

c)

30-45%

d)

25-30%

172.

Which of the following powder properties will influence the capsule size require to fill 400mg of aspirin powder?

a)

Particle size

b)

Equilibrium solubility

c)

Bulk density

173.

Which of the excipients may serve as an effective adsorbing agent to prevent eutectification ?

a)

Talc

b)

Mangesium stereate

c)

Lactose

d)

Sodium lauryl sulfate

174.

Which of the following is/are considered as solid dosage forms?

a)

Tablets

b)

Soft gelatin capsule

c)

Hard gelatin capsule

175.

Which of the following property will play an important role determining effectiveness of the powder for topical application?

a)

Specific surface

b)

True density

c)

Equilibrium solubility

176.

Which of the following is the most commonly used diluent in the conventional immediate release tablet dosage form?

a)

Lactose spray

b)

dried lactose

c)

microcristalline cellulose

177.

1. Which of the following is the most commonly used diluent for chewable tablet?

a)

Lactose

b)

mannitol

c)

mycrocrystalline cellulose

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