NEW
Font size
WorksheetsOAB Part 2
Total questions: 20
Worksheet time: 10mins
Many of Heart failure or peripheral venous and vascular patients describe increased nocturia that manifests as OAB.
True
False
………………………………….. are features of UTI’s not usually associated with OAB.
Dysuria
Possibly elevated temperature
Frequency
Both A & B
As per AUA & SUFU Guidelines, the first line for the treatment of OAB is ………………………….
Behavioral therapy
Antimuscarinics
onabotulinumtoxin A
Neuromodulation
The International Continence Society (ICS) recommends that Pelvic floor muscle therapy be offered as a first-line therapy to all women with stress, urge, or mixed urinary incontinence.
True
False
M1 receptors are distributed in …………………………
Brain
Salivary glands
Smooth muscles
Both A & B
M3 receptors are distributed in ………………………..
Smooth muscles
Glands
Eye
All of the above
On the human detrusor muscle cells, M2 receptors predominate in number over M3 receptors. So M2 receptors are mainly responsible for the normal micturition contraction.
True
False
Antimuscarinic drugs act mainly during the storage phase, decreasing urge and increasing bladder capacity.
True
False
………………………………………… are the mainstay of treatment for OAB.
β-3-receptor agonists
Botulinum toxin A injections
Anti-muscarinic drugs
Flavoxate
All of the following Antimuscuranics are Tertiary amines Except…………………
Solifenacin
Fesoterodine
Trospium
Propiverine
All of the following Anti-muscuranics are FDA approved Except…………………
Tolterodine
Darifenacin
Propiverine
Oxybutynin
Quaternary amines such as solifenacin are not well absorbed, pass into the CNS to a limited extent.
True
False
Tertiary amines such as Trospium are not well absorbed, pass into the CNS to a limited extent.
True
False
The following are Right regarding Trospium EXCEPT
Quaternary amine
pass into the CNS to a limited extent
FDA approved
Has metabolic drug–drug interactions
The following are Right regarding Solifenacin EXCEPT
Predominately M2 selective
Tertiary amine
Not well absorbed
Both A & C
Anti- muscarinics are contraindicated in
Urinary retention
gastric stasis
uncontrolled narrow-angle glaucoma
All of the above
Oxybutynin adversely affect the cognitive function because it’s ………………………………...
Highly lipophilic tertiary amine
Non- selective MRA, acting on M1
Can cross the BBB
All of the above
If anti-muscarinic treatment proves ineffective, consider dose escalation or offering an alternative antimuscuranic formulation, or mirabegron, or a combination.
True
False
The most common treatment-related adverse event in the mirabegron patients are
Constipation
Dry mouth
Hypertension
All of the above
The use of β-3-receptor agonists in men with moderate to severe LUTS who have mainly bladder storage symptoms.( Strong Recommendation – EAU Guidelines 2019)
True
False
