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Pharmacogenetics

Total questions: 10

Worksheet time: 6mins

Name
Class
Date
1.

How is SNP data useful?

a)

the study of evolution

b)

DNA fingerprinting

c)

markers to map polygenic traits

d)

developing genotype specific medication

e)

All of above

2.

SNP stands for

a)

Small nuclear points

b)

Small nuclear polymorphism

c)

Single cell polymorphism

d)

Single nucleotide polymorphism

3.

When 2 alleles are inherited together more often than expected

a)

Linkage

b)

Haplotype

c)

Polymorphism

d)

Linkage disequilibrium

4.

BRCA1 has been linked to ......

a)

Prostate cancer

b)

Cervical cancer

c)

Breast cancer

d)

Liver metabolism

5.

10% of people experience RBC lysis upon consuming fava beans because they lack...,

a)

Oxidoreductase

b)

Glucose phosphate

c)

Glucose 6 phosphate dehydrogenase

d)

Glucose 6 phosphate reductase

6.

>40 different drugs require CYP2D6 to become active, including: antiarrhythmics, opioids, antidepressants, and antipsychotics

a)

True

b)

False

7.

enzyme represented as CYP2C19*1 is a wild type?

a)

Yes

b)

No

8.

Cytochrome P450 3A is used to convert drugs to a form that will be excreted Grapefruit juice contains an unknown component which destroys this enzyme

a)

False

b)

True

9.

Microsattelites are 1-10bp long

a)

True

b)

False

10.

Euchromatic region of DNA is actively transcribing loosely packed region of DNA

a)

True

b)

False