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WorksheetsAdverse Drug Reactions
Total questions: 15
Worksheet time: 15mins
Which of these combination of drug and its adverse effects indicate idiosyncratic drug reaction?
•A- Anticoagulant: Bleeding
•B- Antihypertensive: Hypotension
•C: Antituberculosis: hepatotoxicity
•D- Insulin: Hypoglycaemia
Which of these adverse effects are considered as an emergency?
•A. Abnormal liver function test
•B. Anaphylactic shock
•C. Erythematous rash
•D. Gastrointestinal disturbance
These are considered cutaneous adverse drug reactions that could happen due to allergy to antibiotics EXCEPT
•A- Haematoma
•B- Maculopapular rash
•C- Skin blister
•D- Urticaria (hives)
These are known adverse effect of anticholinergic drugs EXCEPT:
•A- Blurred vision
•B- Dry mouth
•C- Gynaecomastia
•D- Urinary retention
Which of these drugs requires close clinical monitoring to prevent ADR?
•A. Atenolol
•B. Paracetamol
•C. Penicillin
•D. Warfarin
These are combination of drug and its antidote in cases of poisoning EXCEPT:
Atropine - Salbutamol
Digoxin - Digibind
Pancuronium - Neostigmine
Paracetamol - N-acetyl cycteine
A patient is started with drug A, an anticoagulant, to prevent blood clot. Drug A is metabolised by CYP450.
These situations can increase the risk of adverse effects of Drug A (bleeding) EXCEPT?
A. Combination of Drug A with another anticoagulant
B. Combination of Drug A with CYP450 inducer
C. Combination of Drug A with CYP450 inhibitor
D. Double dose of Drug A
What should you do when you suspect and adverse drug reactions?
•A. Take a careful drug history, including over the counter drug
•B. Stop the most probable causative drug taken by the patient
•C. Treat the symptoms
•D. Notify the regulatory agency
•E. All of the above
Which of these is/are valid option to treat adverse drug reaction due to overdose of a drug?
•A- Give ’antidote’ if available
•B- Observe and monitor the condition of patient
•C- Perform gastric lavage
•D- Perform haemodialysis
•E- All of the above
•B- Observe and monitor the condition of patient
•C- Perform gastric lavage
•D- Perform haemodialysis
•E- All of the above
Which of these drugs is known to have a narrow therapeutic index, and can lead to increased risk of ADR?
•A. Antacid
•B. Digoxin
•C. Paracetamol
•D. Penicillin
A 42-year-old man presents with jaundice and right hypochondrial pain 2 weeks following anti-TB drug treatment. Investigations show raised ALT & AST. Causality assessment confirmed that it was anti-TB-drug-induced liver injury (AT-DILI). Investigations also showed that he has a genotype of NAT2 that made him a slow acetylator.
How does being a slow acetylator cause this ADR in this patient?
•Puan Soo has been on warfarin for her valvular heart disease for many years. She reveals that she has recently been treated with ketoconazole for 2 weeks for a fungal infection. Monitoring of her (a) today shows the level prolonged beyond the target level.
•Puan Soo has been on warfarin for her valvular heart disease for many years. She reveals that she has recently been treated with ketoconazole for 2 weeks for a fungal infection. Monitoring of her INR today shows the level prolonged beyond the target level.
•What could have caused the INR to prolong?
Puan Soo has been on warfarin for her valvular heart disease for many years. She reveals that she has recently been treated with ketoconazole for 2 weeks for a fungal infection. Monitoring of her INR today shows the level prolonged beyond the target level.
•What could have happened as a squeal?
•Puan Soo has been on warfarin for her valvular heart disease for many years. She reveals that she has recently been treated with ketoconazole for 2 weeks for a fungal infection. Monitoring of her INR today shows the level prolonged beyond the target level.
Puan Soo could have had spontaneous bleeding/bleeding tendencies. What type of ADR could this have been?
