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WorksheetsLectures 4 to 6
Total questions: 14
Worksheet time: 28mins
1. Activator Protein-1 (AP-1) family members do not include:
JUN
FOS
ATF
MAF
STAT
1. What parameters affect AP-1 activity?
dimer binding partner and the response element to which the AP-1 dimer binds
post-translational modifications to AP-1 members
transcription of AP-1 members by inflammatory cytokines and growth factors
interaction with glucocorticoid receptor (GR) and retinoic-acid receptor (RAR)
all of the above
The bZIP domain (basic leucine zipper domain) is needed
to facilitate formation of dimeric transcription factors.
to methylate DNA
to form beta sheets.
to phosphorylate Src.
Both extrinsic and intrinsic apoptosis pathways aim to activate the executioner caspase, also called
caspase 8
caspase 3
caspase 9
procaspase
none of the above
Phosphatidylserine (PS) is normally
expressed/faces on extracellular layer of bilayer of sick/damaged/dying cells
expressed/faces intracellular layer of bilayer of healthy cells
attracts Annexin V dye
only found in bacterial plasma membranes
What of the following morphological features of are not found in a cell undergoing Ferroptosis?
blebbing of the plasma membrane
small mitochondria with condensed mitochondrial membrane
normal nuclear size and lack of chromatin condensation
enlarged mitochondria
cell no longer flat but rounding-up
Which of the following statements is not true?
MDM2 binds to p53 to block p53 transcriptional activity
MDM2 binds p53 to increase p53 transcriptional activity
p53 function is activated by oxidative stress
p53 target genes function in metabolic homeostasis, DNA repair, growth arrest
Loss of normal p53 function is associated with Li-Fraumeni disease in which humans develop multiple types of cancer.
The function of p53 can be suppressed by the following
mutations
MDM2
nuclear exclusion
PTEN
all of the above
What is the function of PI3K?
Phosphorylate PIP2 to generate PIP3
Dephosphorylate PIP3 to generate PIP2
Degrade p110
none of the above
Insulin binding to the insulin receptor results in phosphorylation of the cytoplasmic domain. How does activated insulin receptor attract PI3K?
The phosphorylated tyrosine on the receptor cytoplasmic region binds the SH2 domains of PI3K
The IRS1/2 binds to the receptor’s phosphorylated region and the phosphate groups on IRS1/2 binds the SH2 domain of PI3K
Both
None of the above
Akt only requires phosphorylated Threonine-308 by mTORC2 to be fully activated.
True
False
Which of the following is not a member of the JAK family?
JAK1
TYK2
JAK3
IL-10
SOCS and CIS proteins are
Products of JAK/STAT signaling
Part of the JAK/STAT Negative Feedback Loop
Kinases that phosphorylate STAT in the absence of JAK
Kinases that help JAK phosphorylate more STAT
How is STAT signaling affected by oxidative stress caused by cigarette smoke condensate extract, UV exposure, or exposure to tumor-derived extracellular vesicles?
Decreases STAT phosphorylation compared to healthy cells
reduces cells surface expression of the cytokine receptor subunit IFNAR1
Increases STAT phosphorylation compared to healthy cells
Has no effect on STAT activation
