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WorksheetsPatho- Immunodeficiencies (exam 4)
Total questions: 16
Worksheet time: 8mins
What is APECED also known as?
APS-1
autoimmune polyendorocrine syndrome
SCID
WAS
Match the opportunistic infections with the immunodeficiency: ear, sinus, lung infections (staphylococcal, streptococcal, pneumococcal, Haemophilus influenzae bacteria; gastrointestinal (enterovirus, Giardia)
antibody
cell-mediated immunity
complement
phagocytes
Match the opportunistic infections with the immunodeficiency: pneumonia (pyogenic bacteria, Pneumocystitis jirovecii, viruses); tuberculosis and other mycobacterial infections, GI (viruses), mycoses of skin and mucous membranes (fungi)
antibody
cell-mediated immunity
complement
phagocytes
Match the opportunistic infections with the immunodeficiency: sepsis and other blood-borne infections (streptococci, pneumococci, Neisseria)
antibody
cell-mediated immunity
complement
phagocytes
Match the opportunistic infections with the immunodeficiency: skin abscesses, reticuloendothelial infections (staphylococci, enteric bacteria, fungi, mycobacteria)
antibody
cell-mediated immunity
complement
phagocytes
Primary immunodeficiencies may cause __________?
recurrent infections
a one time infection to allow antibodies to build
Screening newborn blood samples for TCR gene rearrangement products called ________________.
TCR excision circles
BCR excision circles
What is the main characteristic of SCID?
lack of T cells in the periphery
lack of B cells in the periphery
Primary immunodeficiencies are NOT
are the most common primary immunodeficiencies
are generally not especially severe
do not impair complement fixation
both are the most common primary immunodeficiencies and are generally not especially severe
both are the most common primary immunodeficiencies and do not impair complement fixation
Primary immunodeficiencies affecting T cells tend to be MORE severe than those affecting B cells because
T cells control the innate immune response
T cells regulate antigen presentation
T cells coordinate the adaptive immune response
T cells can trigger apoptosis
Severe combined immunodeficiency (SCID)
is a result of the absence of macrophages or B cells
affects only part of the adaptive immune response
can be caused by failure of TAP transporters
can be caused by failure of V(D)J recombination
Adenosine deaminase deficiency leads to SCID, even though
cells have alternate pathways to use
it primarily affects dendritic cells
it is only used in adults
the gene is not part of the immune system
none of the answers are correct
Hyper IgM syndrome
is autosomal
is a result of a helper T cell defect
includes normal affinity maturation
has impaired cytotoxic T cell responses
HIV-1
is a retrovirus
integrates as a provirus
all of the answers are correct
none of the answers are correct
Because reverse transcriptase is an error-prone enzyme, it follows that
HIV-1 will have a high mutation rate
drugs targeting HIV will affect only part of any population
treatment of HIV will produce temporary results only
all of the answers are correct
none of the answers are correct
Multidrug treatment of HIV-1 is preferred over single-drug treatment because
the high mutation rate of HIV-1 means that many drugs are not likely to work against it
multidrug treatment places a more challenging selective pressure on the virus; to survive requires multiple mutations
protecting itself against one drug makes the virus less able to protect itself against the others
the drugs work synergistically with each other
one drug makes the virus more susceptible to the others
